A skin fixation method for decreasing the influence of wound contraction on wound healing in a rat model.
A skin fixation method for decreasing the influence of wound contraction on wound healing in a rat model.
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皮肤固定方法可减少大鼠模型中伤口收缩对伤口愈合的影响。
DOI：
10.5999/aps.2012.39.5.457
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Choi SJ
中科院分区：
文献类型：
--
作者：
Bae SH;Bae YC;Nam SB;Choi SJ
大鼠背部皮肤的弹性减少了该区域伤口愈合过程中伤口周围的张力，从而激活了伤口收缩。为了减少创面收缩对创面愈合的影响，作者提出了两种利用现成材料的皮肤固定方法，并设计了实验来确定它们的效果。作者在18只大鼠的背部制造了36个皮肤伤口，并将其分为三组。每组分别用三种不同的敷料处理，每种敷料都有不同的皮肤固定特性。A组为对照组。B组和C组分别采用第一和第二种皮肤固定方法进行包扎。术后测量创面面积，计算创面面积缩小率。与对照组相比，两种皮肤固定方法均降低了伤口收缩的效果。两种方法在减少伤口收缩方面的效果各不相同。实验表明，由于创面收缩程度的不同，三组创面面积和创面面积缩小率均有显著差异。为了从伤口愈合实验中获得准确的结果，必须采用适当的皮肤固定方法。
The elasticity of the back skin of the rat reduced the tension around wounds during the wound healing process in that region, and thus activates wound contraction. The authors proposed two skin fixation methods using readily available materials to decrease the influence of wound contraction on wound healing and designed an experiment to determine their effects. The authors made 36 skin wounds on the backs of 18 rats, and they divided them into three groups. Each group was treated with three different kinds of dressing materials, each with different skin fixing characteristics. Group A was a control group. Group B and group C were dressed by the first and the second skin fixation method. We measured the areas of the wounds post-surgically and calculated the wound area reduction rates. The two skin fixation methods both reduced the effect of wound contraction compared to the control group. Each of the two methods had different outcomes in reducing wound contraction. The experiment demonstrated significant differences among the wound areas and the wound area reduction rates of the three groups as a result of differences in the degree of wound contraction. To obtain accurate results from wound healing experiments, appropriate skin fixation methods must be adopted.