Clinical research in OA--the NIH Osteoarthritis Initiative.
Clinical research in OA--the NIH Osteoarthritis Initiative.
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OA 的临床研究——NIH 骨关节炎倡议。
DOI：
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发表时间：
2008
影响因子：
1.9
通讯作者：
G. Lester
中科院分区：
文献类型：
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作者：
G. Lester
确定和描述从发病到关节置换术的疾病。目前有基线、12个月和24个月队列访问的数据和图像。为期36个月的访问数据将于明年公布。该队列中58%为女性，21%为少数族裔。有三个亚组：进展（29%），发生率（68%）和非暴露（3%）。基线年龄在45-79岁之间，年龄分布从最年轻的12%到最年长的23%，中年的30%。每次就诊时均采集生物标本（血液和尿液），并从所有基线标本中提取DNA。这些样品可通过申请获得。2008年，OAI诊所开始对该队列进行第四年也是最后一年的随访（根据现有合同）。美国国立卫生研究院和其他联盟成员已经确定，第三方使用OAI资源产生的经过验证的生物标志物和其他研究工具的广泛可用性对于最大限度地提高该倡议的公共卫生效益是必要的。因此，来自OAI的可再生资源，如临床数据和x射线信息，可以免费提供给各地合格的科学家。这些临床和影像资料自2006年6月起定期在OAI公共网站（http://www.oai.ucsf.edu）上公布。目前，这个公共网站在47个国家有850多名注册用户。已经下载了1500多个临床数据集，并向国内和国际用户分发了87个图像数据集。对于有限的OAI资源，如生物标本，将优先考虑生物标记物的验证，这些生物标记物除了显示科学价值外，还将根据美国国立卫生研究院关于获取和传播生物医学研究资源的原则和指南广泛提供使用。OAI依靠以下临床中心及其主要研究人员：巴尔的摩马里兰大学医学院：Marc Hochberg， m.d.， M.P.H.；俄亥俄州立大学哥伦布分校：丽贝卡·杰克逊，医学博士；匹兹堡大学：C. Kent Kwoh， M.D.；[J]; contemporary medicine; 2008；8 (4): 313 - 314
tify and characterize the disease from onset to joint replacement. There are currently data and images available for the baseline, 12and 24-month visits of the cohort. Data from the 36-month visit will be available in the coming year. The cohort is 58% female with 21% minority enrollment. There are three sub-groups: progression (29%), incidence (68%), and non-exposed (3%). The ages ranged from 45-79 at baseline and the distribution of ages ranges from 12% in the youngest to 23% in the oldest with 30% in the middle years. Biospecimens (blood and urine) are obtained at every visit and DNA has been extracted from all the baseline specimens. These specimens are available by application. The OAI clinics began the fourth and final year (in the existing contract) of follow-up visits for the cohort in 2008. The NIH and other consortium members have determined that widespread availability of validated biomarkers and other research tools arising from use of the OAI resource by third parties is necessary to maximize the public health benefit of the Initiative. Thus, renewable resources from the OAI, such as clinical data and X-ray information, are made freely available to qualified scientists everywhere. These clinical and imaging data have been released to the OAI public web site (http://www.oai.ucsf.edu) at regular intervals since June 2006. Currently there are over 850 registered users of this public web site in 47 countries. Over 1,500 clinical data sets have been downloaded and 87 image data sets have been distributed to national and international users. For OAI resources that are limited, such as the biospecimens, priority will be given to the validation of biomarkers that, in addition to demonstrating scientific merit, will be made widely available for use in accordance with the NIH Principles and Guidelines on Obtaining and Disseminating Biomedical Research Resources. The OAI relies on the following clinical centers and their principal investigators: University of Maryland School of Medicine, Baltimore: Marc Hochberg, M.D., M.P.H.; The Ohio State University, Columbus: Rebecca Jackson, M.D.; University of Pittsburgh: C. Kent Kwoh, M.D.; Memorial J Musculoskelet Neuronal Interact 2008; 8(4):313-314