Seroepidemiology of hepatitis B virus infection: analysis of mass screening in Hawaii
Seroepidemiology of hepatitis B virus infection: analysis of mass screening in Hawaii
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DOI：
10.1007/s12072-008-9103-0
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发表时间：
2008-12-01
影响因子：
6.6
通讯作者：
Ricalde, Aldrich A.
中科院分区：
文献类型：
--
作者：
Tsai, Naoky C. S.;Holck, Peter S.;Ricalde, Aldrich A.
尽管在加利福尼亚和纽约对乙型肝炎的血清患病率进行了广泛的研究，但美国其他高危地区的详细信息尚缺乏。为了研究目前夏威夷乙型肝炎病毒（HBV）感染的流行和风险，我们分析了2003年7月至2006年4月筛查的夏威夷居民的横断面数据。我们回顾性地回顾了在健康博览会和诊所招募的3,989名参与者的筛查记录。使用单变量和多变量logistic回归模型估计HBV感染的患病率和危险因素。乙型肝炎表面抗原（HBsAg）的总患病率为3.6%。性别、年龄和种族与HBsAg血清阳性独立相关。在多变量logistic回归模型中，男性与女性相比HBsAg的风险增加（比值比[OR] = 1.53, 95%可信区间[CI]: 1.09-2.16）， 70岁及以上的人比30岁以下的人更不可能检测出阳性（OR = 0.25, 95% CI: 0.11-0.61）。此外，与白人相比，越南、中国和太平洋岛民HBsAg血清阳性的多变量or分别为3.24 （95% CI: 1.04-10.09）、4.13 （95% CI: 1.66-10.29）和7.47 （95% CI: 2.52-22.11）。这项研究进一步加深了目前对高危移民大量地区HBV流行病学的认识，并证明了乙型肝炎筛查计划的相关性。
Although hepatitis B seroprevalence has been studied extensively in California and New York, detailed information for other high-risk areas in the United States is lacking. To study current prevalence and risk for hepatitis B virus (HBV) infection in Hawaii, we analyzed cross-sectional data from Hawaii residents screened between July 2003 and April 2006.We retrospectively reviewed the screening records of 3,989 participants recruited at health fairs and clinics. Prevalence and risk factors for HBV infection were estimated using univariate and multivariate logistic regression models.Total prevalence of hepatitis B surface antigen (HBsAg) was 3.6%. Gender, age, and ethnicity were independently associated with HBsAg seropositivity. In a multivariate logistic regression model, males were at increased risk for HBsAg compared with females (odds ratio [OR] = 1.53, 95% confidence interval [CI]: 1.09-2.16) and persons aged 70 years or older were less likely to test positive than those younger than 30 (OR = 0.25, 95% CI: 0.11-0.61). In addition, multivariate ORs of HBsAg seropositivity were 3.24 (95% CI: 1.04-10.09), 4.13 (95% CI: 1.66-10.29), and 7.47 (95% CI: 2.52-22.11) for Vietnamese, Chinese, and Pacific Islanders, respectively, compared with Whites.This study furthers current knowledge of HBV epidemiology in areas with large populations of high-risk immigrants and demonstrates the relevance of screening programs for hepatitis B.