Demographics of HIV-1 infection in Denmark: Results from the Danish HIV cohort study
Demographics of HIV-1 infection in Denmark: Results from the Danish HIV cohort study
复制标题
DOI：
10.1080/00365540510031692
复制
发表时间：
2005-05-01
影响因子：
--
通讯作者：
Obel, N
中科院分区：
文献类型：
--
作者：
Lohse, N;Hansen, ABE;Obel, N
我们使用基于人群的队列研究设计来描述丹麦艾滋病毒感染人群的人口特征及其随时间的变化。丹麦的艾滋病毒治疗仅限于9个中心，1995-2003年在这些中心就诊的所有3941名15岁以上的艾滋病毒-1感染者都包括在内。我们发现，艾滋病毒的流行率估计为每10万人中有70人，年平均发病率为每10万人5.1人。新感染人数保持稳定，中位数为每年231人(1995年至2002年期间)，死亡人数从1995年的166人下降到2000年的50人(p=0.000)，此后保持稳定。在登记的患者中，75%是男性，80%是高加索人，13%是非洲黑人，主要危险行为是男性对男性的性接触(44%)、异性接触(36%)和注射吸毒(11%)。在1995年至2003年期间，我们发现确诊年龄增加(p=0.000)，性别、种族、感染模式或基线cd4+细胞计数和病毒载量没有重大变化，无论是整体还是在患者亚组中。在此期间，14.5%的人在被诊断为艾滋病毒时患有艾滋病。我们的数据不能证实人们对丹麦艾滋病毒疫情未经监测的演变的担忧。
We used a population-based cohort study design to describe the demographic characteristics of the HIV-infected population in Denmark and their variation over time. HIV treatment in Denmark is restricted to 9 centres, and all 3941 HIV-1 infected patients more than 15 y old seen at these centres in 1995 - 2003 were included. We found an estimated HIV prevalence of 70 per 100,000, and a mean annual incidence rate of 5.1 per 100,000 persons. The number of newly infected individuals was stable with a median of 231 per y ( period 1995 - 2002), whereas the number of deaths decreased from 166 in 1995 to 50 in 2000 (p = 0.000) and remained stable thereafter. Of the enrolled patients, 75 % were males, 80 % were Caucasian, 13 % were black African, and the primary risk behaviour was male-to-male sexual contact (44 %), heterosexual contact (36 %), and injection drug use (11 %). During the y 1995 - 2003 we found an increase in age at diagnosis (p = 0.000), and no major changes in gender, race, mode of infection, or baseline CD4+ cell count and viral load, neither overall nor within subgroups of patients. In this period 14.5 % had AIDS at the time of HIV diagnosis. Our data do not confirm concerns about unmonitored evolution in the HIV epidemic in Denmark.