Reductive spiroannulation of nitriles with secondary electrophiles.
Reductive spiroannulation of nitriles with secondary electrophiles.
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DOI：
10.1021/ol050567q
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发表时间：
2005-04
期刊：
影响因子：
5.2
通讯作者：
Matthew D. Morin;S. Rychnovsky
中科院分区：
文献类型：
--
作者：
Matthew D. Morin;S. Rychnovsky
还原脱氰和螺环化反应的范围已经扩大到包括次级亲电试剂，用于潜在有用的转化。二级磷酸盐和氯化物以及末端环氧化物以立体特异性方式环化。观察到末端环氧化物的内和外环化模式。
The scope of reductive decyanation and spiroannulation reactions has been expanded to include secondary electrophiles for potentially useful transformations. Secondary phosphates and chlorides, as well as terminal epoxides, cyclize in a stereospecific fashion. Both endo and exo modes of cyclization were observed with terminal epoxides.