Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies
Gray matter alterations in visual cortex of patients with loss of central vision due to hereditary retinal dystrophies
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DOI：
10.1016/j.neuroimage.2011.02.055
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Greenlee, Mark W.
中科院分区：
文献类型：
--
作者：
Plank, Tina;Frolo, Jozef;Greenlee, Mark W.
在中央视野暗斑患者中，大部分视觉皮层没有得到充分的刺激。随着时间的推移，这种输入的缺乏可能导致受影响的皮质区域的灰质减少。我们使用基于体素的形态测量法来研究遗传性视网膜营养不良患者的大脑结构变化，并将其结果与视力正常的受试者进行比较。此外，我们将临床和人口学特征（如疾病持续时间）联系起来。盲点大小、视力、注视稳定性和阅读速度与全脑灰质量的关系。我们发现，与对照组相比，患者视觉皮层病变投射区周围的灰质减少。肌钙沟后部和中部的灰质损失也与暗斑大小有关，这表明确实是缺乏功能性输入引起了灰质的改变。在患者组的全脑回归分析中，我们发现在右上额回和中额回中有一个额外的簇，在额叶视野略前的地方，灰质与注视稳定性正相关。这可以看作是动眼肌学习的结果。(C) 2011爱思唯尔公司版权所有。
In patients with central visual field scotomata a large part of visual cortex is not adequately stimulated. Over time this lack of input could lead to a reduction of gray matter ill the affected cortical areas. We used Voxel Based Morphometry to investigate structural brain changes in patients with central scotomata due to hereditary retinal dystrophies and compared their results to those of normal sighted subjects. Additionally we correlated clinical and demographic characteristics like duration of disease. scotoma size, visual acuity, fixation stability and reading speed to the amount of gray matter in whole brain analyses within the patient group. We found a decrease in gray matter around the lesion projection zone in visual cortex of patients in comparison to controls. Gray matter loss along the posterior and middle portions of the calcarine sulcus is also correlated with scotoma size, indicating that indeed the lack of functional input provokes the gray matter alterations. In whole brain regression analyses within the patient group we found an additional cluster in the right superior and middle frontal gyri, slightly anterior to the frontal eye fields, where gray matter correlated positively with fixation stability. This could he regarded as a consequence of oculomotor learning. (C) 2011 Elsevier Inc. All rights reserved.