Pulmonary function tests versus computed tomography in sheep with experimental emphysema.
Pulmonary function tests versus computed tomography in sheep with experimental emphysema.
复制标题
实验性肺气肿绵羊的肺功能测试与计算机断层扫描。
DOI：
10.1080/019021490944241
复制
发表时间：
2005
影响因子：
1.7
通讯作者：
Ingenito,Edward
中科院分区：
文献类型：
--
作者：
Hoffman,Andrew;Tsai,Larry;Mazan,Melissa;Bellardine,Carissa;Bell,Allison;Lutchen,Ken;Ingenito,Edward
作者探讨了肺功能测试（PFT）和计算机断层扫描（CT）的相对效用，以表征绵羊（n = 12）中木瓜蛋白酶诱导肺气肿的进展。PFT包括体积描记法（FRCpleth）、氦稀释法（FRCHe）和呼气储备量（ERV）。使用木瓜蛋白酶后，FRCplet和FRCHe无变化; ERV降低，因此残气量显著增加（RV + 270 mL，+86%，P = .02）。相比之下，12只绵羊中有10只的CT FRC增加（+264 mL +21%，P = .008）。我们得出结论，体积描记术对肺气肿不敏感，但对ERV的影响（即，捕获气体体积）和通过CT的FRC非常相似，并且与该动物模型中的形态学变化一致。
The authors explored the relative utility of pulmonary function tests (PFTs) and computed tomography (CT) to characterize the progression of papain induced emphysema in sheep (n = 12). PFT included plethysmography (FRCpleth), helium dilution (FRCHe), and expired reserve volume (ERV). Following papain, FRCplethand FRCHewere unchanged; ERV decreased hence residual volume increased significantly (RV + 270 mL, +86%, P = .02). In contrast, FRC by CT increased in 10 of 12 sheep (+264 mL +21%, P = .008). We conclude that plethysmography was insensitive to emphysema, but the effect on ERV (i.e., trapped gas volume) and FRC by CT were very similar, and in line with the morphologic changes in this animal model.