Long sleep duration: a nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: the J-HOP study
Long sleep duration: a nonconventional indicator of arterial stiffness in Japanese at high risk of cardiovascular disease: the J-HOP study
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DOI：
10.1016/j.jash.2016.02.010
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发表时间：
2016-05-01
影响因子：
--
通讯作者：
Kario, Kazuomi
中科院分区：
文献类型：
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作者：
Niijima, Satoshi;Nagai, Michiaki;Kario, Kazuomi
据报道，睡眠时间长和短与高血压、主动脉僵硬和心血管疾病独立相关。高敏 C 反应蛋白 (hs-CRP) 被证明与主动脉僵硬度增加有关。在这里，我们研究了心血管疾病高危老年人的自我报告睡眠持续时间和脉搏波速度（PWV）之间的关系。我们还研究了 hs-CRP 是否调节这种关系。日本 Morning Surge-Home 血压研究招募了 4310 名患有≥1 种心血管风险的患者，完成了一份包含每日睡眠时间项目的调查问卷。我们测量了 2304 名患者（平均年龄 64.7 岁，49.6% 男性）的臂踝 PWV (baPWV) 和 hs-CRP 水平。根据患者的睡眠持续时间（每晚 6 至 8 小时），观察到睡眠持续时间与 PWV 之间存在显着相关性（1594 vs. 1644 vs. 1763 cm/s，P < .0001）。在调整年龄、体重指数、总胆固醇、HbA1c 和临床收缩压的多元回归分析中，当睡眠时间为 6 至 8 小时的患者被定义为参考组时，长睡眠时间（每晚 >= 8 小时）(P < .05) 和 log hs-CRP (P < .05) 与 PWV 显着正相关。观察到不同年龄的长睡眠时间和抗高血压药物对 baPWV 的显着相互作用。长时间睡眠对 PWV 的影响在年龄最大的年龄组中最大。在日本老年人高危人群中，长睡眠时间和 hs-CRP 是 baPWV 增加的重要指标。年龄和抗高血压药物的使用是长睡眠时间和动脉僵硬度之间关系的重要调节因素。 (C) 2016 年美国高血压学会。版权所有。
Long and short sleep durations were reported as independently associated with hypertension, aortic stiffness, and cardiovascular disease. High-sensitivity C-reactive protein (hs-CRP) was shown to be associated with increased aortic stiffness. Here, we investigated the relationship between self-reported sleep duration and pulse wave velocity (PWV) in the elderly at high risk of cardiovascular disease. We also investigated whether hs-CRP moderates this relationship. Among 4310 patients with >= 1 cardiovascular risks recruited for the Japan Morning Surge-Home Blood Pressure Study, a questionnaire including items on daily sleep duration was completed. We measured the brachial-ankle PWV (baPWV) and hs-CRP levels in 2304 of these patients (mean age 64.7 years, 49.6% males). In accord with the patients' sleep duration (= 6 to = 8 hours per night), significant associations between sleep duration and the PWV were observed (1594 vs. 1644 vs. 1763 cm/s, P < .0001). In the multiple regression analysis adjusted for age, body mass index, total cholesterol, HbA1c and clinic systolic blood pressure, long sleep duration (>= 8 hours per night) (P < .05), and log hs-CRP (P < .05) were significantly positively associated with PWV when the patients with 6- to 8-hour sleep duration were defined as a reference group. Significant interactions of long sleep duration by age and that by antihypertensive medication for baPWV were observed. The effect of long sleep on PWV was greatest in the oldest age group. Long sleep duration and hs-CRP were significant indicators of increased baPWV in this elderly high-risk Japanese population. Age and antihypertensive medication use were significant modulators of the relationship between long sleep duration and arterial stiffness. (C) 2016 American Society of Hypertension. All rights reserved.