Responses of plasma concentrations of A type natriuretic peptide and B type natriuretic peptide to alacepril, an angiotensin-converting enzyme inhibitor, in patients with congestive heart failure.
Responses of plasma concentrations of A type natriuretic peptide and B type natriuretic peptide to alacepril, an angiotensin-converting enzyme inhibitor, in patients with congestive heart failure.
复制标题
充血性心力衰竭患者 A 型利钠肽和 B 型利钠肽血浆浓度对血管紧张素转换酶抑制剂阿拉普利的反应。
DOI：
10.1136/hrt.72.6.528
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发表时间：
1994
影响因子：
--
通讯作者：
K. Nakao
中科院分区：
文献类型：
--
作者：
M. Yoshimura;H. Yasue;Hidenori Tanaka;K. Kikuta;H. Sumida;Hideji Kato;M. Jougasaki;K. Nakao
充血性心力衰竭（CHF）患者血浆A型或心钠素（ANP）和B型或脑钠素（BNP）浓度升高。目的--检查CHF患者和对照组口服血管紧张素转换酶（ACE）抑制剂后的血液动力学和激素反应，尤其是ANP和BNP的反应。患者：12名CHF患者和11名对照。方法：口服丙氨蝶呤（37.5mg）后24小时连续测定血液动力学参数和血浆ANP、BNP及其他激素浓度。结果：两组的肺毛细血管楔压和体循环血管阻力均显著降低。心脏指数仅在CHF组增加。在患有CHF的患者中，肺毛细血管楔压、全身血管阻力和心脏指数在阿拉塞鲁肽给药后1至12小时显著改变。心钠素治疗后CHF组血浆ANP、BNP水平明显下降，而对照组无明显变化。在CHF组中，血浆ANP在1至6小时显著降低，并且与肺毛细血管楔压高度显著相关。然而，血浆BNP在丙氨蝶呤治疗后6 - 24小时显著降低，与肺毛细血管楔压无关。结论--丙氨蝶呤给药后血浆BNP的反应比血浆ANP的反应发生得晚，持续时间长。这可能表明两种肽的合成、分泌或降解机制不同。
BACKGROUND--Plasma concentrations of A type or atrial natriuretic peptide (ANP) and B type or brain natriuretic peptide (BNP) are increased in patients with congestive heart failure (CHF). OBJECTIVE--To examine the haemodynamic and hormonal responses, especially of ANP and BNP, to oral administration of an angiotensin-converting enzyme (ACE) inhibitor in patients with CHF and in controls. PATIENTS--12 patients with CHF and 11 controls. METHODS--Haemodynamic variables and plasma concentrations of ANP, BNP, and other hormones were serially measured for 24 hours after alacepril (37.5 mg) was given by mouth. RESULTS--Pulmonary capillary wedge pressure and systemic vascular resistance decreased significantly in both groups. The cardiac index increased only in the CHF group. In patients with CHF pulmonary capillary wedge pressure, systemic vascular resistance, and cardiac index were significantly changed from 1 to 12 hours after alacepril administration. Plasma ANP and BNP decreased significantly after alacepril was given to the CHF group: neither concentration changed in the control group. In the CHF group plasma ANP was significantly lower between 1 and 6 hours and was highly significantly correlated with pulmonary capillary wedge pressure. Plasma BNP, however, was significantly lower between 6 and 24 hours after alacepril and was not correlated with pulmonary capillary wedge pressure. CONCLUSIONS--The response of plasma BNP after alacepril administration occurred later and lasted longer than the plasma ANP response. This may indicate that the mechanisms of synthesis, secretion, or degradation of the two peptides are different.
心房钠尿激素、肾素-醛固酮轴和血压-电解质稳态。
DOI：
10.1056/nejm198511213132106
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Laragh,JH
通讯作者：
Laragh,JH
充血性心力衰竭中神经激素的激活和对转化酶抑制剂的反应。
影响因子：
37.8
作者：
Kubo,SH
通讯作者：
Kubo,SH