Comparison of C-reactive protein levels in less versus more acculturated Hispanic adults in the United States (from the National Health and Nutrition Examination Survey 1999-2008).
Comparison of C-reactive protein levels in less versus more acculturated Hispanic adults in the United States (from the National Health and Nutrition Examination Survey 1999-2008).
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美国文化程度较低的西班牙裔成年人与文化程度较高的西班牙裔成年人的 C 反应蛋白水平比较（来自 1999-2008 年国家健康和营养检查调查）。
DOI：
10.1016/j.amjcard.2011.10.020
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
López,Lenny
中科院分区：
文献类型：
--
作者：
Rodriguez,Fátima;Peralta,CarmenA;Green,AlexanderR;López,Lenny
更大的文化适应与西班牙裔心血管疾病的风险增加有关。c反应蛋白（CRP）是一种炎症标志物，已知与心血管疾病发病率和死亡率增加有关。西班牙人的文化适应是否与CRP水平有关还没有确定。我们研究了1999年至2008年参加国家健康与营养调查（NHANES）的11,858名西班牙裔美国成年人的文化适应与CRP之间的关系。文化适应是通过短文化适应量表（SAS）来测量的，这是一个有效的基于语言的量表。在调整了临床和人口统计学协变量以及适当的抽样权重后，我们使用多元线性回归来检验适应与CRP之间的独立关联。我们将贝塔系数反向转换为相对差值（rd）。较高的文化适应与西班牙人较高的CRP水平独立相关。与文化适应程度较低的西班牙人相比，文化适应程度较高的西班牙人CRP水平RD高52% （p = 0.003）。西班牙裔患者CRP的其他重要预测因素包括较高的体重指数（每5 kg/m2 RD高139%）、女性（RD高36%）、教育水平（至少高中学历的RD高19%，p <0.001）、有保险（RD高27% CRP水平，p = 0.006）、高血压（RD高40% CRP水平，p <0.001）和他汀类药物（RD低22% CRP水平，p = 0.002）。总之，在一项具有全国代表性的人口调查中，较高的文化适应程度与西班牙裔人CRP水平升高有关。炎症可能在解释适应与心血管风险增加之间的关系方面发挥重要作用。
Greater acculturation has been linked to increased risk of cardiovascular disease in Hispanics. C-reactive protein (CRP), a marker of inflammation, is known to be associated with an increased risk of cardiovascular disease morbidity and mortality. Whether acculturation is associated with CRP levels in Hispanics has not been established. We examined the association between acculturation and CRP in 11,858 Hispanic-American adults participating in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2008. Acculturation was measured by the Short Acculturation Scale (SAS), a validated language-based scale. We used multivariate linear regression to examine the independent association between acculturation and CRP after adjusting for clinical and demographic covariates and appropriate sampling weights. We back-transformed the beta coefficients into relative differences (RDs). Higher acculturation was independently associated with higher CRP levels in Hispanics. Compared to those less acculturated, the RD in CRP levels was 52% higher (p = 0.003) for more acculturated Hispanics. Other significant predictors of CRP in Hispanics included a higher body mass index (RD 139% higher per 5 kg/m2), female gender (RD 36% higher), education level (RD 19% higher levels for at least a high school education, p <0.001), being insured (RD 27% higher CRP level, p = 0.006), having hypertension (RD 40% higher CRP levels, p <0.001), and statin use (RD 22% lower CRP levels, p = 0.002). In conclusion, higher acculturation was associated with increased CRP levels in Hispanics in a nationally representative population survey. Inflammation may play an important role in explaining the association between acculturation and increased cardiovascular risk.