Nrf2-dependent gene expressions: a molecular toxicological aspect.
Nrf2-dependent gene expressions: a molecular toxicological aspect.
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DOI：
10.2131/jts.29.81
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发表时间：
2004-05-01
期刊：
影响因子：
--
通讯作者：
Yoshida, Takemi
中科院分区：
文献类型：
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作者：
Numazawa, Satoshi;Yoshida, Takemi
尽管NF-E2相关因子2 （Nrf2）被发现是一种控制β -珠蛋白基因表达的转录调节因子，但现在广泛接受的观点是，这种转录因子是一组蛋白质基因表达的主要调节因子，这些蛋白质作用于抗氧化应激和亲电试剂的解毒。承担转录激活的Nrf2的功能完全取决于其核定位，而核定位受与胞质锚定蛋白Keap1的相互作用及其自身的周转率调控。在本综述中，我们将重点关注Nrf2功能的调控，并讨论该转录因子的生理和毒理学方面的问题。
Although NF-E2 related factor 2 (Nrf2) was found to be a transcriptional regulator that controls an expression of the beta-globin gene, the notion is now widely accepted that this transfactor serves as a master regulator for the gene expression of a battery of proteins acting on anti-oxidative stress and detoxification of electrophiles. The function of Nrf2 that bears transcriptional activation depends solely on its nuclear localization, which is regulated by interaction with the cytosolic anchor protein Keap1 and its own turnover rate. In the present mini-review, we focus on the regulation of Nrf2 function and discuss the physiological and toxicological aspects of this transcriptional factor.