Cell motility dependence on adhesive wetting
Cell motility dependence on adhesive wetting
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DOI：
10.1039/c8sm01832d
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发表时间：
2019-03-07
期刊：
影响因子：
3.4
通讯作者：
Rappel, Wouter-Jan
中科院分区：
文献类型：
--
作者：
Cao, Yuansheng;Karmakar, Richa;Rappel, Wouter-Jan
粘附性细胞-基质相互作用对于细胞运动性至关重要，并且负责推动细胞的必要牵引力。这些相互作用也可以改变细胞的形状，类似于在粘性基底上的液滴润湿。为了解决这些形状变化如何影响细胞迁移和细胞速度，我们使用细胞的可变形的2D横截面来模拟运动性，其中细胞和基底之间的粘附力和摩擦力可以分别变化。我们的模拟表明，增加粘附导致细胞的扩散增加和更大的细胞速度。我们提出了一个分析模型，该模型表明，细胞的速度是成反比的细胞的有效高度，增加这个高度的结果增加内部剪切应力。数值和分析结果证实了在运动的真核细胞的实验。
Adhesive cell-substrate interactions are crucial for cell motility and are responsible for the necessary traction that propels cells. These interactions can also change the shape of the cell, analogous to liquid droplet wetting on adhesive substrates. To address how these shape changes affect cell migration and cell speed we model motility using deformable, 2D cross-sections of cells in which adhesion and frictional forces between cell and substrate can be varied separately. Our simulations show that increasing the adhesion results in increased spreading of cells and larger cell speeds. We propose an analytical model which shows that the cell speed is inversely proportional to an effective height of the cell and that increasing this height results in increased internal shear stress. The numerical and analytical results are confirmed in experiments on motile eukaryotic cells.