A new role of growth hormone and insulin-like growth factor receptor type 1 in neonatal inflammatory nociception: response to commentary.
A new role of growth hormone and insulin-like growth factor receptor type 1 in neonatal inflammatory nociception: response to commentary.
复制标题
生长激素和胰岛素样生长因子受体 1 在新生儿炎症伤害感受中的新作用：对评论的反应。
DOI：
10.1097/pr9.0000000000000609
复制
发表时间：
2017
期刊：
影响因子：
4.8
通讯作者：
Jankowski,MichaelP
中科院分区：
文献类型：
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作者：
Jankowski,MichaelP
作者提供了一个很好的总结，我们最近的报告生长激素（GH）如何调节新生儿炎症性疼痛。我们仍然需要了解GH在外周损伤过程中是如何下调的，以及这种下调如何导致感觉神经元IGFr 1的反常增加。为了澄清，IGF-1在皮肤中没有统计学上的增加。此外，尽管尚未在体内证实，但体外数据表明GH对神经元IGFR 1表达有直接影响。然而，这篇文章强调了接下来的逻辑步骤，我们目前正在寻求阐明生长激素可能提供新生儿镇痛的机制。
The authors provide a nice summary of our recent report on how growth hormone (GH) regulates neonatal inflammatory pain. We still need to understand how GH is downregulated during peripheral injury and how this reduction causes a paradoxical increase in sensory neuron IGFr1. To clarify, IGF-1 was not statistically increased in the skin as suggested. Furthermore, although not confirmed in vivo, in vitro data suggest direct effects of GH on neuronal IGFr1 expression. Nevertheless, this article highlights the next logical steps we are currently pursuing to elucidate mechanisms by which GH may provide neonatal analgesia.