Therapeutic potential of gossypol: An overview
Therapeutic potential of gossypol: An overview
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DOI：
10.3109/13880209.2013.832776
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发表时间：
2014-01-01
影响因子：
3.8
通讯作者：
Goliaei, Bahram
中科院分区：
文献类型：
--
作者：
Keshmiri-Neghab, Hoda;Goliaei, Bahram
背景：多酚是水果、蔬菜、谷物和饮料中天然存在的化合物。多酚类化合物因其药理作用在生物科学中占有独特的地位。棉酚是一种具有生物活性的多酚化合物。目的：据报道，棉酚具有抗生育、抗氧化、抗癌、抗病毒、抗寄生虫、抗微生物和降低血浆胆固醇等作用。结果与结论：这些研究结果对棉酚的生物学作用及其在预防和治疗耐药肿瘤和人类慢性疾病(如HIV、疟疾和银屑病)方面的潜力有了全面的了解。
Context: Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals, and beverages. Polyphenols occupy a unique place in biological science for their pharmacological properties. Gossypol is a polyphenolic compound that has attracted attention because of its biological effects.Objective: Gossypol is reported to exhibit antifertility, antioxidant, anticancer, antivirus, antiparasitic, and antimicrobial properties and lower plasma cholesterol. These are summarized with attention to the mechanisms of activity.Methods: This review summarizes the results of studies obtained in a comprehensive search of ScienceDirect, PubMed, Scirus, and Web of Science.Results and conclusion: The results of these studies provide a comprehensive understanding of the biological action of gossypol and its potential for the prevention of and therapy for resistant tumors and chronic human diseases such as HIV, malaria, and psoriasis.