Association of vascular parkinsonism with impaired neuronal integrity in the striatum
Association of vascular parkinsonism with impaired neuronal integrity in the striatum
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DOI：
10.1007/s00702-006-0610-7
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Fukuyama, H.
中科院分区：
文献类型：
--
作者：
Ihara, M.;Tomimoto, H.;Fukuyama, H.
本研究的目的是利用正电子发射计算机断层扫描(PET)来确定表现为血管性帕金森综合症(VAP)的步态障碍的脑白质病变(WML)患者与未表现为VAP的WML患者之间的潜在差异。将14例MRI诊断为广泛性WMLs的患者分为步态障碍组和非步态障碍组各7例。用[C-11]氟马西尼(FMZ)进行PET扫描，通过非线性曲线拟合计算FMZ(FMZ-V-d)在不同感兴趣区的分布体积，评价神经元的完整性。此外，示踪剂动力学分析用于FMZ-V-d的逐个体素的量化，并使用统计参数映射进行数据分析。纹状体Fmz-V-d值与运动UPDRS评分呈负相关(r=0.70p<；0.005)，且其降低与步态障碍有关。因此，纹状体神经元完整性的差异可能决定WMLs患者是否会发生VAP。
The purpose of this study is to identify the underlying differences between patients with white matter lesions (WMLs) who manifested gait disturbance suggestive of vascular parkinsonism (VaP) and those who did not, using the PET scan. Fourteen patients with extensive WMLs, as determined by MRI, were divided into two groups - 7 with gait disturbance and 7 without it. Neuronal integrity was evaluated with a PET scan using [C-11]flumazenil (FMZ) by calculating the distribution volume of FMZ (FMZ-V-d) in various regions of interest by non-linear curve fitting. Additionally, tracer kinetic analysis was applied for voxel-by-voxel quantification of FMZ-V-d and data analysis was performed using statistical parametric mapping. The striatal FMZ-V-d values were inversely correlated with the motor UPDRS scores (r = 0.70, p < 0.005), and their reductions were associated with the presence of gait disturbance. Therefore, differences in neuronal integrity in the striatum may determine whether patients with WMLs develop VaP or not.