CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia
CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia
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DOI：
10.1007/s00406-013-0427-y
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发表时间：
2014-03-01
影响因子：
4.7
通讯作者：
Gruber, Oliver
中科院分区：
文献类型：
--
作者：
Wolf, Claudia;Mohr, Holger;Gruber, Oliver
情感缺陷是精神分裂症(SZ)、双相情感障碍(BD)和强迫症(OCD)的共同特征之一，杏仁核是参与情绪调节的主要结构之一。以前关于健康对照组和SZ、BD或强迫症患者杏仁核体积差异的研究结果在受影响的大脑半球、大小和作用方向上存在差异。CACNA1C基因的变异与BD、SZ以及健康人和BD患者杏仁核的结构和功能变异有关。我们有兴趣调查杏仁核体积在大脑半球、诊断或基因型组之间是否存在差异，以及是否存在任何交互作用。我们结合CACNA1C中的SNP rs1006737基因分型和结构MRI测量SZ、BD、OCD患者和健康对照组(N(Total)=72)的相对灰质(GM)杏仁核体积。CACNA1C基因对SZ患者杏仁核相对体积有显著影响。在SZ或BD患者中，左侧较右侧杏仁核相对体积显著减小。大脑半球和诊断(对照组与SZ患者)对杏仁核相对体积的影响是基因特异性的。我们的数据表明，CACNA1C基因型可能解释了大脑半球和诊断对杏仁核体积的影响的一些异质性，当与SZ患者和对照组比较时，CACNA1C基因可能解释了SZ患者大脑半球和诊断对杏仁核体积影响的一些异质性，并指出钙信号紊乱是SZ患者病理机制之一。
Affective deficits are one common denominator of schizophrenia (SZ), bipolar disorder (BD) and obsessive compulsive disorder (OCD) with the amygdala indicated as one of the major structures involved in emotion regulation. Previous findings of differences in amygdala volume between healthy controls and patients with SZ, BD or OCD diverge with respect to the affected hemisphere, size and direction of the effect. Variability in the CACNA1C gene has been linked to BD, SZ as well as structural and functional variation in the amygdala in healthy people and patients with BD. We were interested to investigate whether amygdala volumes differ between hemispheres, diagnostic or genotype groups, and whether any interactive effects exist. We combined genotyping of SNP rs1006737 in CACNA1C with structural MRI measurements of relative gray matter (GM) amygdala volume in patients with SZ, BD or OCD as well as healthy controls (N (Total) = 72). The CACNA1C genotype showed a significant effect on relative GM amygdala volume in patients with SZ. There was a significant left versus right relative GM amygdala volume decrease in patients with SZ or BD. The effects of hemisphere and diagnosis (controls vs. patients with SZ) on relative GM amygdala volume were genotype specific. Our data suggest that the CACNA1C genotype may account for some heterogeneity in the effects of hemisphere and diagnosis on amygdala volume when comparing patients with SZ and controls and point to disturbed Ca2+-signaling as a plausible mechanism contributing to the pathology in patients with SZ.