Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank
Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank
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DOI：
10.1186/s12916-020-01640-8
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发表时间：
2020-05-29
期刊：
影响因子：
9.3
通讯作者：
Katikireddi, S. Vittal
中科院分区：
文献类型：
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作者：
Niedzwiedz, Claire L.;O'Donnell, Kate A.;Katikireddi, S. Vittal
背景种族和社会经济地位在SARS-CoV-2感染风险中的作用的理解是有限的。我们调查了这在英国Biobank study.MethodsThe英国Biobank研究招募40-70岁的人在2006-2010年从一般人群中，收集有关自我定义的种族和社会经济变量（包括地区一级的社会经济贫困和教育程度）的信息。英国公共卫生部的SARS-CoV-2检测结果与英国生物库的基线数据相关联。泊松回归与稳健的标准误差被用来评估风险比（RR）之间的曝光和二分变量进行测试，有一个积极的测试和测试阳性的医院。我们还调查了种族和社会经济地位是否与测试中的阳性测试有关。我们调整了协变量，包括年龄，性别，社会变量（包括医疗工作和家庭规模），行为风险因素和基线health. ResultsAmong 392，116参与者在英格兰，2658已被测试为SARS-CoV-2和948测试呈阳性（726在医院）3月16日和2020年5月3日之间。黑人和南亚人群更有可能检测为阳性（分别为RR 3.35（95% CI 2.48-4.53）和RR 2.42（95% CI 1.75-3.36）），南亚人群中巴基斯坦种族的风险最高（RR 3.24（95% CI 1.73-6.07））。与白色英国人相比，这些种族群体更有可能成为医院病例。对基线健康和行为风险因素的调整导致变化不大，在考虑社会经济变量时只有适度的衰减。社会经济贫困和没有资格一直与确诊感染的高风险相关（最贫困四分位数与最贫困四分位数的RR为2.19（95% CI 1.80-2.66），无学历与有学位的RR为2.00（95%CI 1.66-2.42））。结论在英国生物库研究中，一些少数民族群体有较高的确诊SARS-CoV-2感染风险，这不是由社会经济条件、基线自我报告的健康或行为风险因素的差异造成的。需要采取紧急应对措施来应对这些风险。
BackgroundUnderstanding of the role of ethnicity and socioeconomic position in the risk of developing SARS-CoV-2 infection is limited. We investigated this in the UK Biobank study.MethodsThe UK Biobank study recruited 40-70-year-olds in 2006-2010 from the general population, collecting information about self-defined ethnicity and socioeconomic variables (including area-level socioeconomic deprivation and educational attainment). SARS-CoV-2 test results from Public Health England were linked to baseline UK Biobank data. Poisson regression with robust standard errors was used to assess risk ratios (RRs) between the exposures and dichotomous variables for being tested, having a positive test and testing positive in hospital. We also investigated whether ethnicity and socioeconomic position were associated with having a positive test amongst those tested. We adjusted for covariates including age, sex, social variables (including healthcare work and household size), behavioural risk factors and baseline health.ResultsAmongst 392,116 participants in England, 2658 had been tested for SARS-CoV-2 and 948 tested positive (726 in hospital) between 16 March and 3 May 2020. Black and south Asian groups were more likely to test positive (RR 3.35 (95% CI 2.48-4.53) and RR 2.42 (95% CI 1.75-3.36) respectively), with Pakistani ethnicity at highest risk within the south Asian group (RR 3.24 (95% CI 1.73-6.07)). These ethnic groups were more likely to be hospital cases compared to the white British. Adjustment for baseline health and behavioural risk factors led to little change, with only modest attenuation when accounting for socioeconomic variables. Socioeconomic deprivation and having no qualifications were consistently associated with a higher risk of confirmed infection (RR 2.19 for most deprived quartile vs least (95% CI 1.80-2.66) and RR 2.00 for no qualifications vs degree (95% CI 1.66-2.42)).ConclusionsSome minority ethnic groups have a higher risk of confirmed SARS-CoV-2 infection in the UK Biobank study, which was not accounted for by differences in socioeconomic conditions, baseline self-reported health or behavioural risk factors. An urgent response to addressing these elevated risks is required.