Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum
Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum
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从绞股蓝总皂苷水解产物中分离出具有前所未有骨架的三萜类化合物
DOI：
10.1016/j.ejmech.2012.01.052
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发表时间：
2012-04-01
影响因子：
6.7
通讯作者：
Zhao, Yu-Qing
中科院分区：
文献类型：
--
作者：
Li, Ning;Wu, Chun-Fu;Zhao, Yu-Qing
从绞股蓝总皂苷的水解液中分离得到5个新的三萜类化合物，分别鉴定为绞股蓝皂苷元A(1)、绞股蓝皂苷元B(2)、绞股蓝皂苷元C(3)、3-O-β-D-葡萄糖苷-绞股蓝皂苷元D(4)和绞股蓝皂苷元D(5)，其中2个(1和2)具有前所未有的A环结构。化合物1-5对A549、U87和Hep3B三种细胞株具有明显的细胞毒作用，其中化合物3对A549和U87人癌细胞有明显的杀伤活性(IC50值分别为0.11和0.58um)。(C)2012年爱思唯尔·马森公司。版权所有。
Five novel triterpenes were isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum and identified as gypensapogenin A (1), gypensapogenin B (2), gypensapogenin C (3), 3-O-beta-D-glucopyranosyl-gypensapogenin D (4) and gypensapogenin D (5), two of which (1 and 2) possess unprecedented ring A. The cyclization of the side chains-3 formed five-membered cyclic ketone rings similar to ring E in 1. The 21-oic acid-21, 23-lactone was present in the side chains of 4 and 5. We also proposed the possible formation mechanisms of compounds 1-3. Compounds 1-5 were evaluated for cytotoxic activities in three cell lines including A549, U87 and Hep3B and compound 3 showed significant activities toward A549 and U87 human cancer cells (with IC 50 values at 0.11 and 0.58 mu m respectively). (C) 2012 Elsevier Masson SAS. All rights reserved.