Effects of pregnancy and bacterial vaginosis on proinflammatory cytokine and secretory leukocyte protease inhibitor concentrations in vaginal secretions.
Effects of pregnancy and bacterial vaginosis on proinflammatory cytokine and secretory leukocyte protease inhibitor concentrations in vaginal secretions.
复制标题
DOI：
10.1155/2010/385981
复制
发表时间：
2010
影响因子：
3.2
通讯作者：
Hitti J
中科院分区：
文献类型：
--
作者：
Balkus J;Agnew K;Lawler R;Mitchell C;Hitti J
根据细菌性阴道病（BV）的状况，比较孕妇和非孕妇阴道促炎细胞因子和分泌性白细胞蛋白酶抑制剂（SLPI）的浓度。122名妊娠12-20周的妇女和133名未怀孕的对照者用酶免疫分析法测定了阴道白介素(IL)-1β、IL-6、IL-8和SLPI的浓度。采用多变量线性回归评价与阴道细胞因子和SLPI反应独立相关的因素。妊娠和BV均与阴道IL-1β和IL-8浓度升高独立相关；孕妇SLPI浓度升高，而BV患者SLPI浓度降低。
We compared vaginal proinflammatory cytokine and secretory leukocyte protease inhibitor (SLPI) concentrations among pregnant and nonpregnant women according to bacterial vaginosis (BV) status. One-hundred and twenty-two women at 12–20 weeks' gestation and 133 nonpregnant controls had vaginal concentrations of interleukin (IL)-1β, IL-6, IL-8, and SLPI measured by enzyme immunoassay. Multivariable linear regression was used to evaluate factors independently associated with vaginal cytokine and SLPI response. Pregnancy and BV were both independently associated with increased vaginal concentrations of IL-1β and IL-8; pregnant women had increased concentrations of SLPI, while women with BV had decreased SLPI concentrations.