The Thrombopoietin/MPL Pathway in Hematopoiesis and Leukemogenesis
The Thrombopoietin/MPL Pathway in Hematopoiesis and Leukemogenesis
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DOI：
10.1002/jcb.23089
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发表时间：
2011-06-01
影响因子：
4
通讯作者：
Mulloy, James C.
中科院分区：
文献类型：
--
作者：
Chou, Fu-Sheng;Mulloy, James C.
造血干细胞（HSC）占总造血细胞的一小部分。它们的自我更新能力是用新形成的功能性血细胞类型持续补充造血系统的关键，同时保持它们的多潜能能力。了解对HSC维持至关重要的外在信号将提供对造血在其最原始阶段的调节的见解，并且随着知识的应用，将可能导致改善临床移植结果。在这篇综述中，我们将总结目前的理解的作用，血小板生成素/MPL信号通路在造血干细胞维持在成人和胎儿造血。我们还将根据已发表的数据推测该通路的下游关键参与者，并总结该通路在白血病中的作用。J.细胞。112：1491-1498，2011. (C)2011 Wiley-Liss，Inc.
Hematopoietic stem cells (HSC) comprise a small percentage of total hematopoietic cells. Their ability to self-renewal is key to the continuous replenishment of the hematopoietic system with newly formed functional blood cell types while maintaining their multipotential capacity. Understanding the extrinsic signals that are essential to HSC maintenance will provide insights into the regulation of hematopoiesis at its most primitive stage, and with the knowledge applied, will potentially lead to improved clinical transplantation outcomes. In this review, we will summarize the current understanding of the role of the thrombopoietin/MPL signaling pathway in HSC maintenance during adult and fetal hematopoiesis. We will also speculate on the downstream key players in the pathway based on published data, and summarize the role of this pathway in leukemia. J. Cell. Biochem. 112: 1491-1498, 2011. (C) 2011 Wiley-Liss, Inc.