Nanometer site analysis of electron tracks and dose localization in bio-cells exposed to X-ray irradiation
Nanometer site analysis of electron tracks and dose localization in bio-cells exposed to X-ray irradiation
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DOI：
10.1016/j.nimb.2009.02.048
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发表时间：
2009-04-15
影响因子：
1.3
通讯作者：
Sutherland, K. L.
中科院分区：
文献类型：
--
作者：
Date, H.;Yoshii, Y.;Sutherland, K. L.
本文报道了电子径迹中电离团簇和激发团簇的蒙特卡罗模拟分析，这些团簇很可能对生物细胞的辐射损伤有贡献。该研究旨在研究从环境中的低剂量到放射治疗中的高剂量暴露于X射线的细胞核的能量转移。作为一个例子，我们采用一个水模体暴露于X射线从6 MV直线加速器计算预期的能量转移到电子在液态水。对光子相互作用产生的电子进行了径迹模拟。低于1keV的低能电子的行为在形成纳米尺度（<100nm）内的电离和激发事件的簇中是特别重要的。我们描述的聚集模式的聚集指数，分布的点到点的距离低于几个纳米的事件之间。通过与泊松分布的比较，评价了包含连续激进过程的事件的聚集效应。(c)2009爱思唯尔有限公司版权所有。
This paper reports on a Monte Carlo simulation analysis of the ionization and excitation clusters in electron tracks, which may contribute to radiation damage of biological cells with high probabilities. The study is aimed at investigating the energy transfer to the cell nucleus exposed to X-rays from low doses in the environment to high doses in radiation therapy. As an example, we adopt a water phantom exposed to X-rays from a 6 MV linac to calculate the expected energy transfer to electrons in liquid water. A track simulation of the electrons produced by the photon interactions was performed. The behavior of low energy electrons below 1 keV is of particular importance in forming clusters of ionization and excitation events within a nanometer scale (< 100 nm). We describe the clustering pattern in terms of aggregation index, the distribution of point-to-point distance below several nanometers between the events. By comparing the distribution with that of the Poisson configuration, the clustering effects of the events including successive radical processes are evaluated. (c) 2009 Elsevier B.V. All rights reserved.