HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis.
HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis.
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DOI：
10.1016/b978-0-12-396456-4.00002-x
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发表时间：
2012
影响因子：
--
通讯作者：
Connor JH
中科院分区：
文献类型：
--
作者：
Dunn EF;Connor JH
作为细胞过程的专性寄生物，病毒必须接管细胞大分子机器。病毒通常通过直接或间接控制激酶和磷酸酶来控制细胞内信号传导途径，这一点也越来越清楚。这种对细胞磷蛋白的控制对于促进各种病毒过程是重要的，从控制进入核功能到刺激病毒蛋白质合成。本文综述了各种逆转录病毒、DNA病毒和RNA病毒对细胞磷脂酰肌醇-3-激酶（PI 3 K）/Akt信号通路的接管，强调了病毒激活PI 3 K和Akt活性的功能。本文还介绍了PI 3 K/Akt通路在宿主反应中的作用，指出它可以触发抗-以及前病毒功能。
As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to promote a variety of viral processes, from control of entry to nuclear function to the stimulation of viral protein synthesis. This review focuses on the takeover of the cellular phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway by a variety of retroviruses, DNA viruses, and RNA viruses, highlighting the functions ascribed to virus activation of PI3K and Akt activity. This review also describes the role that the PI3K/Akt pathway plays in the host response, noting that it that can trigger anti- as well as proviral functions.