Correlated Low-Frequency BOLD Fluctuations in the Resting Human Brain Are Modulated by Recent Experience in Category-Preferential Visual Regions
Correlated Low-Frequency BOLD Fluctuations in the Resting Human Brain Are Modulated by Recent Experience in Category-Preferential Visual Regions
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DOI：
10.1093/cercor/bhp270
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发表时间：
2010-08-01
期刊：
影响因子：
3.7
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
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作者：
Stevens, W. Dale;Buckner, Randy L.;Schacter, Daniel L.
静息脑与显著的内在活动波动相关，例如通过功能性磁共振成像测量的相关低频（IF）血氧水平依赖（BOLD）波动。尽管最近扩展了研究静息状态LF-BOLD相关性的研究，但对其性质和功能知之甚少。IF-BOLD相关性的一个主要限制似乎是解剖连接的稳定特性。也有证据表明，耦合可以调制最近或正在进行的任务性能，这表明相关的动态的某些组件是可塑性的短时间尺度。在这里，我们比较了活动在延长休息时间后的性能2个不同的认知任务，使用不同类别的视觉刺激面孔和复杂的场景。长时间暴露于这些不同类别的视觉信息导致额叶网络耦合差异后类别优先视觉区域在随后的休息期间。此外，我们报告的初步证据表明，条件存在的LF-BOLD相关性的调制程度预测随后的记忆。这一发现，休息状态IF-BOLD的相关性调制最近的经验，在功能特定的大脑区域从事在以前的任务性能澄清了他们的作用，作为一个动态的现象，可能涉及记忆过程。
The resting brain is associated with significant intrinsic activity fluctuations, such as the correlated low-frequency (IF) blood oxygen level-dependent (BOLD) fluctuations measured by functional magnetic resonance imaging. Despite a recent expansion of studies investigating resting-state LF-BOLD correlations, their nature and function are poorly understood. A major constraint on IF-BOLD correlations appears to be stable properties of anatomic connectivity. There is also evidence that coupling can be modulated by recent or ongoing task performance, suggesting that certain components of correlated dynamics are malleable on short timescales. Here, we compared activity during extended periods of rest following performance of 2 distinct cognitive tasks using different categories of visual stimuli faces and complex scenes. Prolonged exposure to these distinct categories of visual information caused frontal networks to couple differentially with posterior category-preferential visual regions during subsequent periods of rest. In addition, we report preliminary evidence suggesting that conditions exist in which the degree of modulation of LF-BOLD correlations predicts subsequent memory. The finding that resting-state IF-BOLD correlations are modulated by recent experience in functionally specific brain regions engaged during prior task performance clarifies their role as a dynamic phenomenon which may be involved in mnemonic processes.