THE RESPIRATORY RETENTION OF BACTERIAL AEROSOLS - EXPERIMENTS WITH RADIOACTIVE SPORES
THE RESPIRATORY RETENTION OF BACTERIAL AEROSOLS - EXPERIMENTS WITH RADIOACTIVE SPORES
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DOI：
10.1017/s0022172400015801
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发表时间：
1953-01-01
影响因子：
--
通讯作者：
MORTON, JD
中科院分区：
文献类型：
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作者：
HARPER, GJ;MORTON, JD
采用Druet、May、亨德森、Packman和Peacock的方法研究了吸入颗粒物的滞留部位和程度。使用枯草芽孢杆菌的孢子。通过培养B使孢子具有放射性。枯草芽孢杆菌在含有P32的培养基中作为Na 2 HPO 4。然后使用Druett和May装置制备标记孢子的气溶胶。将豚鼠、猴和小鼠暴露于气雾剂，并在暴露后立即或长达24小时内处死并进行检查。暴露后。检查头部、气管、肺、胃和肠道的孢子。他们观察到保留在头部的孢子比例随着颗粒尺寸的增加而增加。有直径的微粒。在1 [mu]的颗粒中，仅3-7%的孢子被保留，而在直径为6[mu]的颗粒中，75-85%的孢子被保留在头部中。气管绝不会保留大量的孢子。当孢子离开头部时，它们直接进入肺部或胃的深处;从那里它们很快就从身体中消失了。
By means of the methods of Druet, May, Henderson, Packman, and Peacock, the site and degree of retention of inhaled particles were studied. The spores of Bacillus subtilis were used. The spores were made radioactive by growing B. subtilis in a medium containing P32 as Na2HPO4. Aerosols of the labelled spores were then made with the Druett and May apparatus. Guinea pigs, monkeys, and mice were exposed to the aerosols and were killed and examined either Immediately after exposure or up to 24 hrs. after exposure. The head, trachea, lungs, stomach, and gut were examined for the spores. They observed that the proportion of spores retained in the head increased with increased particle size. With particles of a diam. of 1 [mu], only 3-7% of the spores were retained, whereas with particles having a diameter of 6[mu], 75-85% were retained in the head. The trachea never retained the spores in great nos.. When the spores left the head, they passed directly to the deep recesses of the lungs or to the stomach; from there they were rather quickly removed from the body.