Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men.
Differences in Factors Associated With High- and Low-Risk Oral Human Papillomavirus Genotypes in Men.
复制标题
男性高风险和低风险口腔人乳头瘤病毒基因型相关因素的差异。
DOI：
10.1093/infdis/jiaa693
复制
发表时间：
2021
期刊：
影响因子：
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通讯作者：
Giuliano,AnnaR
中科院分区：
文献类型：
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作者：
Bettampadi,Deepti;Dickey,Brittney;Abrahamsen,Martha;Sirak,Bradley;Baggio,MariaLuiza;Galan,Lenice;Silva,RobertoCarvalho;Villa,Luisa;Ponce,EduardoLazcano;Giuliano,AnnaR
BackgroundHuman papillomavirus (HPV) causes oral warts and oropharyngeal cancer (OPC). Human papillomavirus-attributable OPC incidence among men is significantly increasing worldwide, yet few studies have reported oral HPV across multiple countries or examined factors associated with low- and high-risk HPV separately.MethodsOral gargles from 3095 men in the multinational HPV Infection in Men (HIM) Study were HPV genotyped. Multivariable models assessed factors independently associated with high-risk and low-risk HPV prevalence.ResultsThe prevalence of high-risk and low-risk HPV was 6.0% and 2.8%, respectively. Greater number of sexual partners was only associated with high-risk HPV (1.88; 95% confidence interval [CI], 1.22–2.90) prevalence. In multivariable models, residing in Mexico (1.66; 95% CI, 1.15–2.40) and smoking (1.66; 95% CI, 1.13–2.44) were significantly associated with high-risk HPV, and history of consistent gum bleeding (2.16; 95% CI, 1.35–3.45) was significantly associated with low-risk HPV. Gender of the sexual partner did not alter the results for either high- or low-risk HPV endpoints.ConclusionsDifferent factors were independently associated with high- and low-risk oral HPV. Oral sexual behaviors were associated with high-risk HPV, and oral health was associated with low-risk HPV. High-risk HPV prevalence differed by country of residence, highlighting the need for additional studies in multiple countries.
