Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
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DOI：
10.1038/ng.1102
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发表时间：
2012-01-29
期刊：
影响因子：
30.8
通讯作者：
Baker, Suzanne J.
中科院分区：
文献类型：
--
作者：
Wu, Gang;Broniscer, Alberto;McEachron, Troy A.;Lu, Charles;Paugh, Barbara S.;Becksfort, Jared;Qu, Chunxu;Ding, Li;Huether, Robert;Parker, Matthew;Zhang, Junyuan;Gajjar, Amar;Dyer, Michael A.;Mullighan, Charles G.;Gilbertson, Richard J.;Mardis, Elaine R.;Wilson, Richard K.;Downing, James R.;Ellison, David W.;Zhang, Jinghui;Baker, Suzanne J.
为了鉴定儿科弥漫性内在脑桥胶质瘤（DIPG）中的体细胞突变，我们对7例DIPG和匹配的生殖系DNA进行了全基因组测序，并对另外43例DIPG和36例非脑干儿科胶质母细胞瘤（非BS-PG）进行了靶向测序。78%的DIPG和22%的非BS-PG在编码组蛋白H3.3的H3 F3 A或编码组蛋白H3.1的相关HIST 1H 3B中含有p.K27M突变。另外14%的非BS-PG具有体细胞p.G34R H3 F3 A突变。
To identify somatic mutations in paediatric diffuse intrinsic pontine gliomas (DIPGs), we performed whole genome sequencing of 7 DIPGs and matched germline DNA, and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem paediatric glioblastomas (non-BS-PGs). 78% of DIPGs and 22% of non-BS-PGs contained p.K27M mutation in H3F3A, encoding histone H3.3, or the related HIST1H3B, encoding histone H3.1. An additional 14% of non-BS-PGs had somatic p.G34R H3F3A mutations.
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影响因子：
64.5
作者：
Goldberg AD;Banaszynski LA;Noh KM;Lewis PW;Elsaesser SJ;Stadler S;Dewell S;Law M;Guo X;Li X;Wen D;Chapgier A;DeKelver RC;Miller JC;Lee YL;Boydston EA;Holmes MC;Gregory PD;Greally JM;Rafii S;Yang C;Scambler PJ;Garrick D;Gibbons RJ;Higgs DR;Cristea IM;Urnov FD;Zheng D;Allis CD
通讯作者：
Allis CD
影响因子：
45.3
作者：
Paugh, Barbara S.;Broniscer, Alberto;Baker, Suzanne J.
通讯作者：
Baker, Suzanne J.
影响因子：
45.3
作者：
Paugh, Barbara S.;Qu, Chunxu;Baker, Suzanne J.
通讯作者：
Baker, Suzanne J.
DOI：
10.1126/science.1164382
发表时间：
2008-09-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Parsons DW;Jones S;Zhang X;Lin JC;Leary RJ;Angenendt P;Mankoo P;Carter H;Siu IM;Gallia GL;Olivi A;McLendon R;Rasheed BA;Keir S;Nikolskaya T;Nikolsky Y;Busam DA;Tekleab H;Diaz LA Jr;Hartigan J;Smith DR;Strausberg RL;Marie SK;Shinjo SM;Yan H;Riggins GJ;Bigner DD;Karchin R;Papadopoulos N;Parmigiani G;Vogelstein B;Velculescu VE;Kinzler KW
通讯作者：
Kinzler KW
影响因子：
5.8
作者：
Broniscer, A;Gajjar, A
通讯作者：
Gajjar, A