Novel Internationally Verified Method Reports Desmoplastic Reaction as the Most Significant Prognostic Feature For Disease-specific Survival in Stage II Colorectal Cancer
Novel Internationally Verified Method Reports Desmoplastic Reaction as the Most Significant Prognostic Feature For Disease-specific Survival in Stage II Colorectal Cancer
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DOI：
10.1097/pas.0000000000001304
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发表时间：
2019-09-01
影响因子：
5.6
通讯作者：
Ueno, Hideki
中科院分区：
文献类型：
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作者：
Nearchou, Ines P.;Kajiwara, Yoshiki;Ueno, Hideki
多种组织病理学特征已被报道为预测侵袭性II期结直肠癌(CRC)的候选指标。这些包括肿瘤萌发(TB)、低分化丛集(PDC)、克罗恩样淋巴反应和促结缔组织增生反应(DR)分类。尽管它们的个体预后意义已经确定，但它们与疾病特异性生存(DSS)的相关性在II期结直肠癌中尚未被比较。这项研究旨在评估和比较日本人(n=283)和苏格兰人(n=163)队列中上述特征的预后价值，并比较两种不同的报告方法：从整个肿瘤的每个组织载玻片分析每个特征，以及从包含最深肿瘤侵袭的单个载玻片报告每个特征。在日本的队列中，多载玻片和单载玻片方法在结核病、肺结核和DR方面有很好的一致性(kappa=0.798-0.898)，在评估克罗恩样淋巴反应时也有很好的一致性(kappa=0.616)。结核病(危险比[HR]=1.773；P=0.016)、肺结核(HR=1.706；P=0.028)和DR(HR=2.982；P
Multiple histopathologic features have been reported as candidates for predicting aggressive stage II colorectal cancer (CRC). These include tumor budding (TB), poorly differentiated clusters (PDC), Crohn-like lymphoid reaction and desmoplastic reaction (DR) categorization. Although their individual prognostic significance has been established, their association with disease-specific survival (DSS) has not been compared in stage II CRC. This study aimed to evaluate and compare the prognostic value of the above features in a Japanese (n=283) and a Scottish (n=163) cohort, as well as to compare 2 different reporting methodologies: analyzing each feature from across every tissue slide from the whole tumor and a more efficient methodology reporting each feature from a single slide containing the deepest tumor invasion. In the Japanese cohort, there was an excellent agreement between the multi-slide and single-slide methodologies for TB, PDC, and DR (kappa=0.798 to 0.898) and a good agreement when assessing Crohn-like lymphoid reaction (kappa=0.616). TB (hazard ratio [HR]=1.773; P=0.016), PDC (HR=1.706; P=0.028), and DR (HR=2.982; P