Lung organogenesis.
Lung organogenesis.
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DOI：
10.1016/s0070-2153(10)90003-3
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发表时间：
2010
影响因子：
--
通讯作者：
Jesudason, Edwin
中科院分区：
文献类型：
--
作者：
Warburton, David;El-Hashash, Ahmed;Carraro, Gianni;Tiozzo, Caterina;Sala, Frederic;Rogers, Orquidea;De Langhe, Stijn;Kemp, Paul J.;Riccardi, Daniela;Torday, John;Bellusci, Saverio;Shi, Wei;Lubkin, Sharon R.;Jesudason, Edwin
发育肺生物学是一个有可能对人类产生重大影响的领域：极端年龄的肺病继续在世界范围内造成严重的发病率和死亡率。了解肺是如何发育的有望使研究人员利用这一知识来帮助肺修复和再生。自从肺的“分子胚胎学”第一次被全面回顾以来的十年里，出现了新的挑战--我们目前的综述重点就是这些挑战。首先，为了开发干细胞治疗肺部疾病的潜力，迫切需要了解肺的祖细胞生物学。其次，目前熟悉的由生长和转录因子控制的肺形态发生的描述需要详细阐述，并重新考虑其他因素，如在肺生长中的力学因素。第三，解析肺芽信号的更细微细节的努力可能需要与更广泛地考虑可能更容易达到治疗目标的总体机制相结合：在这一领域，我们提出从时钟的角度看待总体(特别是分支)肺可能会产生意想不到的好处的建议。
Developmental lung biology is a field that has the potential for significant human impact: lung disease at the extremes of age continues to cause major morbidity and mortality worldwide. Understanding how the lung develops holds the promise that investigators can use this knowledge to aid lung repair and regeneration. In the decade since the “molecular embryology” of the lung was first comprehensively reviewed, new challenges have emerged—and it is on these that we focus the current review. Firstly, there is a critical need to understand the progenitor cell biology of the lung in order to exploit the potential of stem cells for the treatment of lung disease. Secondly, the current familiar descriptions of lung morphogenesis governed by growth and transcription factors need to be elaborated upon with the reinclusion and reconsideration of other factors, such as mechanics, in lung growth. Thirdly, efforts to parse the finer detail of lung bud signaling may need to be combined with broader consideration of overarching mechanisms that may be therapeutically easier to target: in this arena, we advance the proposal that looking at the lung in general (and branching in particular) in terms of clocks may yield unexpected benefits.