The effect of oral l-carnitine on lipoprotein composition in the Watanabe Heritable Hyperlipidemic Rabbit (Oryctolagus cuniculus).
The effect of oral l-carnitine on lipoprotein composition in the Watanabe Heritable Hyperlipidemic Rabbit (Oryctolagus cuniculus).
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DOI：
10.1016/0300-9629(87)90071-5
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
T. L. Raymond;S. A. Reynolds;J. A. Swanson;C. Patnode;F. Bell
中科院分区：
文献类型：
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作者：
T. L. Raymond;S. A. Reynolds;J. A. Swanson;C. Patnode;F. Bell
1.我们最近报道的能力，口服左旋肉碱，以降低血浆甘油三酯在渡边遗传性高脂血症兔（WHHL），一种动物模型的家族性高脂蛋白血症。2.在目前的研究中，我们研究了在这个动物模型中的L-肉毒碱管理后，个别脂蛋白亚组分的影响。3.肉碱喂养导致极低密度脂蛋白（VLDL）和高密度脂蛋白（HDL）的减少。4.成分分析显示，核心甘油三酯含量减少，伴随着蛋白质和磷脂的VLDL和低密度脂蛋白（LDL）的增加。5.相反，电泳迁移率和载脂蛋白组成与左旋肉碱不变。6.这些结果进一步证明了L-肉毒碱在该家族性高脂蛋白血症动物模型中调节脂蛋白脂质组成的能力。
1. We have recently reported the ability of orally administered l-carnitine to lower plasma triglyceride in the Watanabe Heritable Hyperlipidemic Rabbit (WHHL), an animal model of familial hyperlipoproteinemia. 2. In the present studies we examined the effect of l-carnitine administration upon individual lipoprotein subfractions in this animal model. 3. Carnitine feeding resulted in a reduction in very low density lipoproteins (VLDL) and high density lipoprotein (HDL). 4. Compositional analysis revealed a reduction in core triglyceride content with a concomitant increase in protein and phospholipid in VLDL and low density lipoproteins (LDL). 5. Conversely, electrophoretic mobility and apolipoprotein composition were unchanged with l-carnitine. 6. These results further demonstrate the ability of l-carnitine to modulate lipoprotein lipid composition in this animal model of familial hyperlipoproteinemia.