Direct Amination of Azoles via Catalytic C-H, N-H Coupling
Direct Amination of Azoles via Catalytic C-H, N-H Coupling
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DOI：
10.1021/ol900298e
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发表时间：
2009-04-02
期刊：
影响因子：
5.2
通讯作者：
Mori, Atsunori
中科院分区：
文献类型：
--
作者：
Monguchi, Daiki;Fujiwara, Taiki;Mori, Atsunori
C-H、N-H在铜催化剂的存在下，唑与几种胺发生偶联，在2-位进行胺化。苯并噻唑与N-甲基苯胺在乙酸钠和20mol%醋酸铜（2）存在下，二甲苯中于氧气气氛下反应，得到胺化产物，产率为81%。
C-H, N-H Coupling of azoles takes place with several amines in the presence of a copper catalyst to undergo amination at the 2-position. The reaction of benzothiazole with N-methylaniline in the presence of sodium acetate and 20 mol % Cu(OAc)(2) in xylene under an oxygen atmosphere afforded the aminated product in 81% yield.