Detection of tumor response to radiation therapy by in vivo proton MR spectroscopy
Detection of tumor response to radiation therapy by in vivo proton MR spectroscopy
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DOI：
10.1016/s0360-3016(96)00371-9
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发表时间：
1996-10-01
影响因子：
7
通讯作者：
Glickson, JD
中科院分区：
文献类型：
--
作者：
Bhujwalla, ZM;Glickson, JD
目的：这些研究旨在研究辐射对 H-1 磁共振波谱 (MRS) 检测到的代谢物（例如乳酸和胆碱化合物）水平的影响。目的是确定空间定位 H-1 MRS 检测肿瘤对放射治疗的反应的能力。方法和材料：在 2、4 和 20 Gy 伽马射线照射之前以及之后 24 和 48 小时从体素空间分辨率为 8-16 mm(3) 的 RIF-1 肿瘤获得质子光谱图像。结果：所有剂量的乳酸水平在 48 小时内均显着下降。接受 2 和 4 Gy 照射的肿瘤在 48 小时内表现出显着减少，但在 24 小时时没有出现明显下降。一组假照射对照动物在观察期间没有表现出乳酸的显着变化。结论：本研究中观察到的乳酸变化与先前研究 (15) 中在相同肿瘤模型中接受 20 Gy X 射线照射后观察到的血液增加一致。这些研究指出了检测对临床剂量的反应的可行性。 H-1 MRS 分段放射治疗。版权所有 (C) 1996 爱思唯尔科学公司。
Purpose: These studies were performed to investigate the effects of radiation on levels of metabolites such as lactate and choline compounds detected by H-1 magnetic resonance spectroscopy (MRS). The purpose was to determine the ability of spatially localized H-1 MRS to detect tumor response to radiation therapy.Methods and Materials: Proton spectroscopic images were obtained from RIF-1 tumors with voxel spatial resolutions of 8-16 mm(3) before and at 24 and 48 h following 2, 4, and 20 Gy of gamma-radiation.Results: Lactate levels decreased significantly for all doses by 48 h. Tumors irradiated with 2 and 4 Gy showed a significant decrease by 48 h, but not at 24 h, A group of sham-irradiated control animals demonstrated no significant changes in lactate over the period of observation.Conclusions: Changes in lactate observed in this study are consistent with an increased blood Bow observed in previous studies (15) in the same tumor model following 20 Gy X-irradiation, These studies point to the feasibility of detecting response to clinical doses of fractionated radiation therapy by H-1 MRS. Copyright (C) 1996 Elsevier Science Inc.