ISACGH:: a web-based environment for the analysis of array CGH and gene expression which includes functional profiling
ISACGH:: a web-based environment for the analysis of array CGH and gene expression which includes functional profiling
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DOI：
10.1093/nar/gkm257
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发表时间：
2007-07-01
影响因子：
14.9
通讯作者：
Dopazo, Joaquin
中科院分区：
文献类型：
--
作者：
Conde, Lucia;Montaner, David;Dopazo, Joaquin
我们提出了ISACGH，一个基于网络的系统，允许基因组数据与基因表达值相结合，并提供不同的选项功能分析的区域发现。几个可视化选项提供了一个方便的表示结果。不同的有效方法，准确估计基因组拷贝数阵列CGH杂交数据已包括在程序中。此外，与基因表达分析包GEPAS的连接允许使用不同的设施进行数据预处理和分析。DAS服务器允许将结果导出到Ensembl查看器，其中可以获得上下文基因组信息。该程序可在http://isacgh.bioinfo.cipf.es或http://www.gepas.org内免费获得。
We present the ISACGH, a web-based system that allows for the combination of genomic data with gene expression values and provides different options for functional profiling of the regions found. Several visualization options offer a convenient representation of the results. Different efficient methods for accurate estimation of genomic copy number from array-CGH hybridization data have been included in the program. Moreover, the connection to the gene expression analysis package GEPAS allows the use of different facilities for data pre-processing and analysis. A DAS server allows exporting the results to the Ensembl viewer where contextual genomic information can be obtained. The program is freely available at: http://isacgh.bioinfo.cipf.es or within http://www.gepas.org.