Development and function of tissue-resident memory B cells.
Development and function of tissue-resident memory B cells.
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DOI：
10.1016/bs.ai.2022.08.001
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发表时间：
2022-01-01
影响因子：
--
通讯作者：
Laidlaw, Brian J
中科院分区：
文献类型：
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作者：
Chen, Changfeng;Laidlaw, Brian J
屏障组织是可能导致未来大流行的病原体的主要感染部位。组织驻留淋巴细胞可以在屏障组织感染后快速检测病原体，并且在防止病毒传播方面至关重要。然而，大多数疫苗不能诱导组织驻留淋巴细胞，而是依赖于循环抗体来介导保护性免疫。接种疫苗后，循环抗体滴度随时间推移而下降，使个体容易受到逃避抗体中和的变异病毒株的突破性感染。最近发现记忆B细胞在屏障组织感染后建立组织驻留。在这里，我们总结了新出现的证据的重要性，组织驻留记忆B细胞在建立保护性免疫对病毒和细菌的挑战。我们还讨论了组织驻留记忆B细胞在调节非感染性疾病进展中的作用。最后，我们研究了新的方法来开发能够引发屏障免疫的疫苗。
Barrier tissues are the primary site of infection for pathogens likely to cause future pandemics. Tissue-resident lymphocytes can rapidly detect pathogens upon infection of barrier tissues and are critical in preventing viral spread. However, most vaccines fail to induce tissue-resident lymphocytes and are instead reliant on circulating antibodies to mediate protective immunity. Circulating antibody titers wane over time following vaccination leaving individuals susceptible to breakthrough infections by variant viral strains that evade antibody neutralization. Memory B cells were recently found to establish tissue residence following infection of barrier tissues. Here, we summarize emerging evidence for the importance of tissue-resident memory B cells in the establishment of protective immunity against viral and bacterial challenge. We also discuss the role of tissue-resident memory B cells in regulating the progression of non-infectious diseases. Finally, we examine new approaches to develop vaccines capable of eliciting barrier immunity.