Progestin receptors with and without estrogen induction in male and female hamster brain.
Progestin receptors with and without estrogen induction in male and female hamster brain.
复制标题
雄性和雌性仓鼠大脑中有和没有雌激素诱导的孕激素受体。
作者：
I. G. Fraile;D. Pfaff;B. McEwen
用合成配体（~ 3 H）R5020在去性腺仓鼠的脑和垂体中检测到孕激素受体。在测量结合前48小时用苯甲酸雌二醇激发动物，可以显着增加雄性和雌性中发现的受体数量。总孕激素结合活性的皮质，下丘脑视前区和垂体的两种性别是相同的，当高剂量的雌激素（30微克每只动物）用于诱导，但诱导的男性受体被发现性腺切除术后随着时间的推移而下降。这些研究结果进行了讨论，在性腺切除仓鼠的攻击和性行为的影响，孕酮。
Progestin receptors have been detected in the brain and pituitary of gonadectomized hamsters using the synthetic ligand (3H)R5020. The number of receptors found in males and females could be dramatically increased by priming the animals with estradiol benzoate 48 h before the binding was measured. Total progestin-binding activity in the cortex, hypothalamus-preoptic area and pituitary of both sexes was the same when high doses of estrogen (30 micrograms per animal) were used for induction, but the inducibility of the male receptors was found to decline with time after gonadectomy. These findings are discussed in relation to the effects of progesterone on aggressive and sexual behaviors in gonadectomized hamsters.