True carcinosarcoma of the esophagus
True carcinosarcoma of the esophagus
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DOI：
10.1111/j.1442-2050.2006.00538.x
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Masuda, T
中科院分区：
文献类型：
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作者：
Iwaya, T;Maesawa, C;Masuda, T
大多数食管癌肉瘤被诊断为所谓的癌肉瘤，其中单个成分可能来源于单个共同的祖先细胞，并且有一些报道描述了真正的癌肉瘤起源于两个单独的干细胞。我们报告一例食管癌肉瘤表现为肿瘤样骨形成。vimentin和p53的免疫反应性仅限于肉瘤成分，而在癌成分中不存在。此外，p53基因外显子7的点突变仅在肉瘤成分中观察到。肉瘤和癌细胞都明显转移到不同的淋巴结。这些观察结果使我们诊断该食道肿瘤为真正的癌肉瘤。
Most esophageal carcinosarcomas are diagnosed as so-called carcinosarcoma, in which individual elements may be derived from a single common ancestor cell, and there have been a few reports describing true carcinosarcoma originating from two individual stem cells. We describe a case of esophageal carcinosarcoma exhibiting neoplastic osteoid formation. Immunoreactivity for vimentin and p53 was limited to only the sarcomatous component and was absent in the carcinomatous component. Furthermore, a point mutation in exon 7 of the p53 gene was observed only in the sarcomatous component. Both sarcoma and carcinoma cells distinctively metastasized to different lymph nodes. These observations led us to diagnose the esophageal tumor as a true carcinosarcoma.