Congenital diaphragmatic eventration with absent left phrenic nerve in the fetal pig
Congenital diaphragmatic eventration with absent left phrenic nerve in the fetal pig
复制标题
胎猪先天性膈膨出伴左膈神经缺失
DOI：
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发表时间：
2019
影响因子：
1.2
通讯作者：
Y. Takashima
中科院分区：
文献类型：
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作者：
S. Sekiya;Honami Oota;Yukari Maruyama;M. Sakaihara;Y. Takashima
我们遇到了一个胎猪与横膈膜外翻和肺发育不全并膈神经发育不全。胎猪为雌性，冠臀长34厘米，体重约1500克。横膈膜是一个完整的连续片，但由一层半透明的膜组成，残留的肌肉组织仅在横膈膜右叶的背外侧区域。左边的叶子特别地向胸腔方向突出。左膈神经完全缺失，而右膈神经有少许残余，支配右叶背外侧肌肉区。双肺均小，细支气管产生的小细支气管数量减少至正常肺的一半左右。此外，左右锁骨下肌肉和神经无法识别。这些发现表明，横膈膜、锁骨下肌和支配它们的神经组成了一个发育模块，这将继发影响肺的发育。认为本病例类似于人类先天性膈肌外翻的动物模型。
We encountered a fetal pig with eventration of the diaphragm and pulmonary hypoplasia accompanied by phrenic nerve agenesis. The fetal pig was female measuring 34 cm in crown-rump length and about 1500 g in body weight. The diaphragm was a complete continuous sheet, but comprised a translucent membrane with residual muscular tissue only at the dorsolateral area of the right leaf of the diaphragm. The left leaf protruded extraordinarily toward the thoracic cavity. The left phrenic nerve was completely absent, while there was a slight remnant of the right phrenic nerve that supplied the dorsolateral muscular area of the right leaf. Both lungs were small, and the number of smaller bronchioles arising from the bronchioles was decreased to about half of that of the normal lung. Additionally, the right and left subclavius muscles and nerves could not be identified. These findings imply that the diaphragm, the subclavius muscle and nerves innervating them comprise a developmental module, which would secondarily affect lung development. It is considered that the present case is analogous to the animal model of congenital eventration of the diaphragm in humans.