SYNTHESIS OF CAT MUSCLE ACETYLCHOLINE RECEPTORS BY XENOPUS OOCYTES
SYNTHESIS OF CAT MUSCLE ACETYLCHOLINE RECEPTORS BY XENOPUS OOCYTES
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爪蟾卵母细胞合成猫肌肉乙酰胆碱受体
DOI：
10.2220/biomedres.3.390
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发表时间：
1982
影响因子：
1.2
通讯作者：
Katsumi Sumikawa
中科院分区：
文献类型：
--
作者：
R. Miledi;Katsumi Sumikawa
从有神经支配或去神经支配的猫肌肉中提取信使RNA （mRNA）注射到爪蟾卵母细胞中。来自两种肌肉的mRNA指导乙酰胆碱（ACh）受体的合成，这些受体被合并到卵母细胞膜中。在注入神经支配肌肉的卵母细胞中，乙酰胆碱对这些受体的激活是一种膜电位大于负10毫伏的内向电流
Messenger RNA (mRNA) extracted from innervated or denervated cat muscles was injected into Xenopus oocytes. mRNA from both types of muscle directed the synthesis of acetylcholine (ACh) receptors, which became incorporated into the oocyte membrane. Activation of these receptors by ACh an inward current at membrane potentials more negative than 10 mV. for ACh action in oocytes injected innervated muscle