Bergamotane Sesquiterpenes with Alpha-Glucosidase Inhibitory Activity from the Plant Pathogenic Fungus Penicillium expansum
Bergamotane Sesquiterpenes with Alpha-Glucosidase Inhibitory Activity from the Plant Pathogenic Fungus Penicillium expansum
复制标题
来自植物病原真菌扩展青霉的具有α-葡萄糖苷酶抑制活性的佛手柑倍半萜
DOI：
10.1002/cbdv.201600184
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发表时间：
2017-01-01
影响因子：
2.9
通讯作者：
Zhan, Zha-Jun
中科院分区：
文献类型：
--
作者：
Ying, You-Min;Fang, Cheng-An;Zhan, Zha-Jun
从植物病原真菌Penicillium expansum ACCC37275 中分离出两种新的佛手柑倍半萜内酯，命名为expansolides C 和D（1 和2），以及两种已知化合物expansolides A 和B（3 和4）。通过对光谱数据，特别是 1D-、2D-NMR 和 HR-ESI-MS 的详细分析，确定了新化合物的结构。在体外生物测定中，与阳性对照阿卡波糖 (IC50 = 1.90 +/- 0.05 mm) 相比，膨胀固体 C 和 D (1 和 2) 的差向混合物（在生物测定温度下比例为 2:1）表现出更有效的 β-葡萄糖苷酶抑制活性 (IC50 = 0.50 +/- 0.02 mm)。据我们所知，这是第一份关于佛手柑倍半萜的β-葡萄糖苷酶抑制活性的报告。
Two new bergamotane sesquiterpene lactones, named expansolides C and D (1 and 2), together with two known compounds expansolides A and B (3 and 4), were isolated from the plant pathogenic fungus Penicillium expansum ACCC37275. The structures of the new compounds were established by detailed analyses of the spectroscopic data, especially 1D-, 2D-NMR, and HR-ESI-MS. In an in vitro bioassay, the epimeric mixture of expansolides C and D (1 and 2) (in a ratio of 2:1 at the temprature of the bioassay) exhibited more potent -glucosidase inhibitory activity (IC50 =0.50 +/- 0.02 mm) as compared with the positive control acarbose (IC50 = 1.90 +/- 0.05 mm). To the best of our knowledge, it was the first report on the -glucosidase inhibitory activity of bergamotane sesquiterpenes.