Lung injury and bronchopulmonary dysplasia in newborn infants.
Lung injury and bronchopulmonary dysplasia in newborn infants.
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DOI：
10.1177/0885066604273494
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发表时间：
2005-03-01
影响因子：
3.1
通讯作者：
Brodsky, Dara
中科院分区：
文献类型：
--
作者：
Christou, Helen;Brodsky, Dara
支气管肺发育不良是存活的早产儿中最常见的发病率。对发育中的肺的损伤是易感宿主与许多致病因素相互作用的结果，如机械通风和感染。由此导致的持续肺功能损害和持续治疗是支气管肺发育不良的基本特征。对支气管肺发育不良发病机制的重要见解导致了许多治疗和预防方法。虽然已经取得了重大进展，但为了进一步影响疾病的发病率和严重程度，我们需要进一步研究(A)遗传决定的易感因素，(B)各种致病途径的相对贡献，以及(C)如何最好地将从这些研究中获得的知识转化为有效的临床方法。
Bronchopulmonary dysplasia is the most common morbidity among surviving premature infants. Injury to the developing lung is the result of the interaction between a susceptible host and a number of contributing factors such as mechanical ventilation and infection. The resulting persistent impairment of pulmonary function and need for ongoing therapy are the underlying characteristics of bronchopulmonary dysplasia. Important insights into the pathogenesis of bronchopulmonary dysplasia have led to numerous therapies and preventive approaches. Although significant progress has been made, in order to further affect the incidence and severity of the disease, we need to further study (a) the genetically determined predisposing factors, (b) the relative contribution of the various pathogenetic pathways, and, most important, (c) how to best translate the knowledge gained from these studies into effective clinical approaches.