Oxygen effect on lung cells.
Oxygen effect on lung cells.
复制标题
氧气对肺细胞的影响。
DOI：
10.1001/archinte.1971.00310190058005
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发表时间：
1971
影响因子：
--
通讯作者：
E. Weibel
中科院分区：
文献类型：
--
作者：
E. Weibel
在一个大气压下呼吸纯氧会导致肺泡毛细血管内皮细胞的原发性破坏;鳞状上皮细胞继发性受损，而发现颗粒肺细胞再生立方上皮衬里和空气空间。由于细胞层的渗透性改变，间质和肺泡水肿随之发生。血液学的变化在肺氧中毒的发展中的作用进行了讨论。
Breathing pure oxygen at one atmosphere leads to primary destruction of alveolar capillary endothelial cells; squamous epithelial cells are damaged secondarily, whereas granular pneumocytes are found to regenerate a cuboidal epithelium lining and air spaces. Interstitial and alveolar edema ensue as a consequence of permeability changes in the cell layers. The role of hematological changes in the development of pulmonary oxygen toxicity is discussed.