Alzheimer's disease is a synaptic failure
Alzheimer's disease is a synaptic failure
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DOI：
10.1126/science.1074069
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发表时间：
2002-10-25
期刊：
影响因子：
56.9
通讯作者：
Selkoe, DJ
中科院分区：
文献类型：
--
作者：
Selkoe, DJ
在其早期临床阶段，阿尔茨海默病的特点是产生明显的纯粹的记忆损伤。越来越多的证据表明，这种综合征始于明显的神经元变性之前海马突触功能的细微改变，突触功能障碍是由淀粉样蛋白的扩散寡聚体引起的。
In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.