Diaphragm plasticity following intrinsic laryngeal muscle denervation in rats.
Diaphragm plasticity following intrinsic laryngeal muscle denervation in rats.
复制标题
大鼠内在喉肌去神经后膈肌的可塑性。
DOI：
10.1097/00005768-200202000-00012
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发表时间：
2002
影响因子：
4.1
通讯作者：
Farkas,GasparA
中科院分区：
文献类型：
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作者：
Rodman,JoshuaR;Gosselin,LucE;Horvath,PeterJ;Megirian,David;Farkas,GasparA
RODMAN，JR，LE GOSSELIN，PJ HORVATH，D. Megirian和GA Farkas。大鼠喉内肌失神经支配后膈肌的可塑性。医学科学体育锻炼：Vol. 34，No. 2，pp. 251-257，2002.目的在吸气过程中，喉内肌（ILM）的募集减少了吸气泵肌肉上的吸气负荷。我们的研究的目的是确定1）是否隔膜适应去神经支配的ILM，和2）是否额外的刺激运动训练的影响程度，隔膜适应ILM denervation. MethodsThirteen的雄性SD大鼠（2个月）被随机分为久坐不动的控制（SC），久坐不动，去神经支配（SD），和运动去神经支配（艾德）组。对照组动物进行假手术，而ILM去神经动物进行双侧喉返神经横断。手术后三周，动物在艾德组进行了为期6 wk.ResultsDenervation（SD和艾德动物）的ILM的跑步机训练协议显着增加隔膜柠檬酸合酶活性（20%），在体外耐力，和时间达到峰值抽搐张力（15%），并减少（13%）峰值强直张力（Po，N· cm 2）。没有独立的训练效果以上的影响归因于去神经支配的ILM被注意到在艾德animals.ConclusionThe结果突出的作用，声带扩张功能在eupnea和运动引起的呼吸过度。关键词：环杓后肌、声门、膈肌适应性、柠檬酸合酶、膈肌顺应性
RODMAN, JR, LE GOSSELIN, PJ HORVATH, D. MEGIRIAN, and GA FARKAS. Diaphragm plasticity following intrinsic laryngeal muscle denervation in rats. Med. Sci. Sports Exerc., Vol. 34, No. 2, pp. 251–257, 2002.PurposeDuring inspiration, recruitment of the intrinsic laryngeal muscles (ILM) reduces the inspiratory load on the ventilatory pump muscles. The purpose of our study was to determine 1) whether the diaphragm adapts to denervation of the ILM, and 2) whether the additional stimulus of exercise training affects the degree to which the diaphragm adapts to ILM denervation.MethodsThirty-six male Sprague-Dawley rats (2 months) were randomly divided into sedentary control (SC), sedentary-denervated (SD), and exercise-denervated (ED) groups. Control animals underwent sham operations, whereas ILM-denervated animals underwent bilateral transection of the recurrent laryngeal nerves. Three weeks after surgery, animals in the ED group performed a treadmill training protocol for a period of 6 wk.ResultsDenervation (SD and ED animals) of the ILM significantly increased diaphragm citrate synthase activity (20%), in vitro endurance, and time to peak twitch tension (15%), and reduced (13%) peak tetanic tension (Po, N· cm 2). No independent training effect over and above the effects attributed to denervation of ILM were noted in ED animals.ConclusionThe results highlight the role of vocal cord dilator function during both eupnea and exercise-induced hyperpnea. Key Words: POSTERIOR CRICOARYTENOID MUSCLE, GLOTTIC APERTURE, DIAPHRAGM ADAPTABILITY, CITRATE SYNTHASE, DIAPHRAGM CONTRACTILITY