Propranolol and sotalol metabolism after a drinking party
Propranolol and sotalol metabolism after a drinking party
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饮酒聚会后普萘洛尔和索他洛尔的代谢
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
P. Järvensivu
中科院分区：
文献类型：
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作者：
E. Sotaniemi;M. Anttila;A. Rautio;J. Stengård;Pekka Saukko;P. Järvensivu
研究了晚宴饮酒对健康受试者β肾上腺素能受体阻滞剂代谢和反应的影响。这些药物是在第一次饮酒后12小时服用的。在肝脏中代谢的普萘洛尔的血浆清除率增加，而消除不变的索他洛尔的血浆清除率降低。血浆普萘洛尔水平与血液酒精含量有关，而索他洛尔水平与血浆普萘洛尔水平无关。心得安的降压作用在酒精后减弱，索他洛尔的降压作用增强。这两种药物都降低了酒精后的心率，尽管它们无法完全抵消酒精导致的心率增加。结果表明，饮酒可能会改变β阻断药物的代谢。在使用β阻断药物进行治疗时，或者在寻找治疗无效的心绞痛或动脉高血压的原因时，必须考虑饮酒习惯。
The effects of alcohol consumed during an evening party on the metabolism and response of β‐adrenergic blocking drugs were investigated in healthy subjects. The drugs were given 12 hr after the first drink. The plasma clearance rate of propranolol, metabolized in the liver, increased, while that of sotalol, which is eliminated unchanged, was reduced. Plasma propranolol levels, but not those of sotalol, were related to blood alcohol content. The blood pressure–reducing effect of propranolol diminished after alcohol and that of sotalol increased. Both drugs reduced the heart rate after alcohol although they were unable to cancel out entirely the alcohol‐induced increase in the heart rate. The results show that drinking may alter the metabolism of β‐blocking drugs. Drinking habits must be considered in therapy with β‐blocking drugs or when seeking reasons for angina pectoris or arterial hypertension that does not respond to therapy.