Efficacy of chronic antidepressant treatments in a new model of extreme anxiety in rats.
Efficacy of chronic antidepressant treatments in a new model of extreme anxiety in rats.
复制标题
DOI：
10.1155/2011/531435
复制
发表时间：
2011
影响因子：
--
通讯作者：
Messaoudi M
中科院分区：
文献类型：
--
作者：
Javelot H;Weiner L;Terramorsi R;Rougeot C;Lalonde R;Messaoudi M
在人类中发现的焦虑症的动物模型，如恐慌症和创伤后应激障碍，通常包括自发的和条件性的恐惧，触发逃避和回避行为。惊恐障碍模型的发展与学习的组成部分，应增加知识的机制参与焦虑症。在我们的行为学模型的极度焦虑的大鼠，强迫呼吸暂停结合冷水蒸发在一个不可避免的情况。根据媒介物对照的反应，涉及阵发性恐惧的行为是被动（冻结）和主动（跳跃）反应。我们的研究结果表明，亚慢性氟西汀（5 mg/kg，IP，21天）和丙咪嗪（10 mg/kg，IP，14天）管理减轻冻结和跳跃行为，而急性氟西汀（1 mg/kg，IP）引起相反的效果。急性低剂量地西泮（1 mg/kg，IP）无效，而高剂量3 mg/kg，IP和氯硝西泮（1 mg/kg，IP）仅对跳跃有影响。因此，在这种实验条件下产生的阵发性恐惧可能与焦虑症患者中观察到的恐惧学相似。
Animal models of anxious disorders found in humans, such as panic disorder and posttraumatic stress disorder, usually include spontaneous and conditioned fear that triggers escape and avoidance behaviors. The development of a panic disorder model with a learned component should increase knowledge of mechanisms involved in anxiety disorders. In our ethological model of extreme anxiety in the rat, forced apnea was combined with cold water vaporization in an inescapable situation. Based on the reactions of vehicle controls, behaviors involved in paroxysmic fear were passive (freezing) and active (jumping) reactions. Our results show that subchronic fluoxetine (5 mg/kg, IP, 21 days) and imipramine (10 mg/kg, IP, 14 days) administration alleviated freezing and jumping behaviors, whereas acute fluoxetine (1 mg/kg, IP) provoked opposite effects. Acute low dose of diazepam (1 mg/kg, IP) was not effective, whereas the higher dose of 3 mg/kg, IP, and clonazepam (1 mg/kg, IP) only had an effect on jumping. Paroxysmic fear generated in this experimental condition may therefore mimic the symptomatology observed in patients with anxiety disorders.