Structure Elucidation of Submilligram Quantities of Natural Products - Application to Haliclamines G and H from the Arctic Marine Sponge Haliclona viscosa
Structure Elucidation of Submilligram Quantities of Natural Products - Application to Haliclamines G and H from the Arctic Marine Sponge Haliclona viscosa
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DOI：
10.5560/znb.2012-0039
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发表时间：
2012-09-01
影响因子：
0.8
通讯作者：
Koeck, Matthias
中科院分区：
文献类型：
--
作者：
Cychon, Christine;Schmidt, Gesine;Koeck, Matthias
利用改进的层析条件和对卤素的碎裂模式的详细了解，直接从北极海绵的粗提物中鉴定出两种新的卤素。它们是具有两个等长的烷基(10个亚甲基)的卤胺G(1)和具有10和12个亚甲基的烷基链的卤胺H(2)。由于海绵材料的数量有限，卤素类化合物没有被分离出来，结构的确定依赖于与合成化合物的色谱和质谱学比较。
Two new haliclamines were identified directly from the crude extract of the Arctic sponge Haliclona viscosa using improved chromatographic conditions and a detailed knowledge about the fragmentation pattern of haliclamines. These are haliclamine G (1) with two alkyl chains of equal length (10 methylene groups) and haliclamine H (2) with alkyl chains of 10 and 12 methylene groups. Due to the limited amount of sponge material available, the haliclamines were not isolated, and the structure elucidation relied on the chromatographic and mass spectrometric comparison with synthetic compounds.