Angiogenesis and bone growth
Angiogenesis and bone growth
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DOI：
10.1016/s1050-1738(00)00074-8
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发表时间：
2000-07-01
影响因子：
9.3
通讯作者：
Ferrara, N
中科院分区：
文献类型：
--
作者：
Gerber, HP;Ferrara, N
生长板区域的血管化代表了决定骨生长速率的两个基本过程耦合的关键机制，即软骨形成（软骨生成）和成骨（骨形成）。在成人骨骼快速生长或骨折修复期间，精确耦合至关重要，平衡的变化可能会诱发骨关节炎和异位骨形成等病理状况。在长骨生长板的形成过程中，发育中的血管结构和软骨（体内血管最少的组织之一）之间存在着密切而动态的相互作用。最近的实验结果解释了为什么软骨和脉管系统的紧密接近是相互排斥的：软骨的血管侵入与软骨细胞凋亡相关，因此，生长板中血管生成的抑制延迟了软骨细胞的死亡，导致生长板中肥大软骨细胞数量的大量增加。软骨细胞在骨骼生长、发育和修复中的根本重要性促使人们对调节软骨细胞成熟和凋亡的机制进行深入研究。 (C) 2001，Elsevier Science Inc. 保留所有权利。
Vascularization of the growth plate region represents a key mechanism for the coupling of two fundamental processes determing the rate of bone growth, chondrogenesis (cartilage production) and osteogenesis (bone formation). Precise coupling is crucial during periods of rapid bone growth or fracture repair in adults, and changes in the balance might induce pathologic conditions such as osteoarthritis and ectopic bone formation. During the formation of the growth plates of long bones, there is a close and dynamic interaction between developing vascular structures and the cartilage, which is one of the least vascular tissues in the body. Recent experimental findings provide an explanation why the close proximity of cartilage and vasculature is mutually exclusive: vascular invasion of cartilage is associated with chondrocyte apoptosis and consequently, inhibition of angiogenesis in the growth plate delays chondrocyte cell death, resulting in. a massive expansion in the number of hypertrophic cartilage cells in the growth plate. The fundamental importance of chondrocytes in the growth, development and repair of the skeleton has Zed to intense investigation of the mechanisms that regulate chondrocyte maturation and apoptosis. (C) 2001, Elsevier Science Inc. All rights reserved.