Is Age-Related Macular Degeneration a Microvascular Disease?
Is Age-Related Macular Degeneration a Microvascular Disease?
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DOI：
10.1007/978-1-4614-3209-8_36
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Stone, Edwin M.
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文献类型：
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作者：
Mullins, Robert F.;Khanna, Aditi;Stone, Edwin M.
视网膜相关性黄斑变性（AMD）是一种常见的中央视网膜退行性疾病，仅在美国就影响数百万老年人，在世界范围内也有更多的老年人。更好地了解AMD的病理生理学对于开发新的治疗方法至关重要。在这篇综述中，我们讨论了补体复合物沉积在脉络膜毛细血管老化的眼睛和脉络膜毛细血管损失和玻璃疣形成之间的关系的潜在影响。我们进一步提出了一个模型，整合了遗传和解剖学研究结果在AMD和建议的影响，这些研究结果为未来的治疗。
Age-related macular degeneration (AMD) is a common, degenerative disease of the central retina affecting millions of elderly in the USA alone and many more worldwide. A better understanding of the pathophysiology of AMD will be essential for developing new treatments. In this review, we discuss the potential impact of complement complex deposition at the choriocapillaris of aging eyes and the relationship between choriocapillaris loss and drusen formation. We further propose a model that integrates genetic and anatomical findings in AMD and suggest the implications of these findings for future therapies.