Antiviral Chinese medicinal herbs against respiratory syncytial virus
Antiviral Chinese medicinal herbs against respiratory syncytial virus
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DOI：
10.1016/s0378-8741(01)00389-0
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发表时间：
2002-02-01
影响因子：
5.4
通讯作者：
Lee, SF
中科院分区：
文献类型：
--
作者：
Ma, SC;Du, J;Lee, SF
用细胞病理效应(CPE)法检测了44种中草药对呼吸道合胞病毒(RSV)的抑制作用。44种中草药中有27种对呼吸道合胞病毒有较强或中等的抗病毒活性，半数抑制浓度(IC50)为6.3~52.1µg/ml，选择性指数(SI)为2.0~32.1。苦参活性提取物的进一步纯化。和黄芩中的苦参碱(2)、氧化苦参碱(7)、苦参素(10)、汉黄素(12)和苦参素A(13)为有效抗RSV活性成分。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC50) ranging from 6.3 to 52.1 mug/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.