REQUIREMENT FOR SUBPLATE NEURONS IN THE FORMATION OF THALAMOCORTICAL CONNECTIONS
REQUIREMENT FOR SUBPLATE NEURONS IN THE FORMATION OF THALAMOCORTICAL CONNECTIONS
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DOI：
10.1038/347179a0
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发表时间：
1990-09-13
期刊：
影响因子：
64.8
通讯作者：
SHATZ, CJ
中科院分区：
文献类型：
--
作者：
GHOSH, A;ANTONINI, A;SHATZ, CJ
成人大脑皮层第4层的神经元主要接受来自丘脑的上行输入。然而，在发育过程中，丘脑轴突在其目标第4层神经元迁移到皮质板之前很久就到达了适当的皮质区域。轴突在皮质板下方的区域（亚板）积聚并等待数周，然后侵入皮质板。亚板是一个短暂的区域，包含端脑的第一个有丝分裂后神经元。这些神经元比其他皮质神经元成熟得更早，并且在丘脑轴突已经生长到覆盖的皮质板中之后通过细胞死亡而消失。近距离生长的丘脑皮质轴突和subplate神经元表明，他们可能参与正常的丘脑皮质发育的重要相互作用。在这里，我们表明，在发展的早期，位于视觉皮层下的subplate神经元的缺失，防止从丘脑外侧膝状体核的轴突识别和支配视觉皮层，他们的正常目标。在亚板神经元的情况下，外侧膝状体核轴突继续在经过视觉皮层的白色物质中生长，尽管存在它们的靶层4神经元。因此，瞬时亚板神经元对于丘脑皮质轴突选择适当的皮质靶点是必要的。
THE neurons of layer 4 in the adult cerebral cortex receive their major ascending inputs from the thalamus. In development, however, thalamic axons arrive at the appropriate cortical area long before their target layer 4 neurons have migrated into the cortical plate. The axons accumulate and wait in the zone below the cortical plate, the subplate, for several weeks before invading the cortical plate. The subplate is a transient zone that contains the first postmitotic neurons of the telencephalon. These neurons mature well before other cortical neurons, and disappear by cell death after the thalamic axons have grown into the overlying cortical plate. The close proximity of growing thalamocortical axons and subplate neurons suggests that they might be involved in interactions important for normal thalamocortical development. Here we show that early in development the deletion of subplate neurons located beneath visual cortex prevents axons from the lateral geniculate nucleus of the thalamus from recognizing and innervating visual cortex, their normal target. In the absence of subplate neurons, lateral geniculate nucleus axons continue to grow in the white matter past visual cortex despite the presence of their target layer 4 neurons. Thus the transient subplate neurons are necessary for appropriate cortical target selection by thalamocortical axons.