Leptin-induced decrease in food intake is not associated with changes in gastric emptying in lean mice
Leptin-induced decrease in food intake is not associated with changes in gastric emptying in lean mice
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DOI：
10.1152/ajpregu.1997.272.3.r1007
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发表时间：
1997-03-01
影响因子：
2.8
通讯作者：
Tache, Y
中科院分区：
文献类型：
--
作者：
Barrachina, MD;Martinez, V;Tache, Y
瘦素的长期治疗可以调节肥胖和瘦小鼠的体重和能量平衡，并减少食物摄入量。在禁食 18 至 20 小时的瘦小鼠（C57BL/6，+/+）中，我们检查了单次腹腔注射重组小鼠瘦素（0.12 mg/kg）对食物摄入和胃排空的急性影响。瘦素减少了食物摄入量，在注射后第 5 小时达到峰值抑制（69 +/- 12%/小时），尽管第 1 小时食物消耗量没有变化。瘦素不会改变固体营养餐的 4 小时胃排空率（在 1、2 或 4 小时内自由食用普瑞纳饲料）。在禁食 18-20 小时的正常 Sprague-Dawley 大鼠中，单次腹腔注射重组小鼠瘦素（0.2 或 1.2 mg/kg）不会改变 7 小时累积或每小时食物摄入量。这些结果表明，单次腹腔注射重组小鼠瘦素可在 5 小时内减少食物摄入量，同时不影响瘦小鼠摄入食物的胃排空。在注射后 4-7 小时内，单次腹腔注射小鼠瘦素，剂量比小鼠有效剂量高 10 倍，Sprague-Dawley 大鼠对减少食物摄入的效果没有反应。
Chronic treatment with leptin regulates body weight and energy balance and reduces food intake in obese and lean mice. In 18- to 20-h fasted lean mice (C57BL/6, +/+), we examined the acute effect of a single intraperitoneal injection of recombinant mouse leptin (0.12 mg/kg) on food intake and gastric emptying. Leptin reduced food intake, with a peak inhibition at the 5th h postinjection (69 +/- 12%/h), although there was no change in food consumption at the Ist h. Leptin did not alter the 4-h rate of gastric emptying of a solid nutrient meal (free access to Purina chow for either 1-, 2-, or 4-h period). In normal Sprague-Dawley rats fasted for 18-20 h, a single intraperitoneal injection of recombinant mouse leptin (0.2 or 1.2 mg/kg) did not modify the 7-h cumulative or hourly food intake. These results show that a single intraperitoneal injection of recombinant mouse leptin reduces food intake within 5 h while not influencing gastric emptying of ingested food in lean mice. Sprague-Dawley rats are unresponsive to the food intake-reducing effect of a single intraperitoneal injection of mouse leptin at a dose 10-fold higher than that shown to be effective in mice within the first 4-7 h postinjection.